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Saikosaponin A

Catalog No. T2768   CAS 20736-09-8

Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropathic pain in CCI rats by inhibiting the activation of p38 MAPK and NF-κB signaling pathways in spinal cord. It can inhibit NMDA receptor current and persistent sodium current, and inhibit the TNF-α level, the IL-1β production, and cysteine-aspartic acid protease (caspase)-1 activity.

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Saikosaponin A Chemical Structure
Saikosaponin A, CAS 20736-09-8
Pack Size Availability Price/USD Quantity
1 mg In stock $ 34.00
5 mg In stock $ 72.00
10 mg In stock $ 126.00
25 mg In stock $ 247.00
50 mg In stock $ 409.00
100 mg In stock $ 596.00
1 mL * 10 mM (in DMSO) In stock $ 115.00
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Purity: 99.88%
Purity: 98.76%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Saikosaponin A has a variety of pharmacological benefits, including antiepileptic, anti-osteoporosis, antioxidant, anti-in ammatory, immunomodulatory, and anti-bacterial activities. It can effectively attenuate neuropathic pain in CCI rats by inhibiting the activation of p38 MAPK and NF-κB signaling pathways in spinal cord. It can inhibit NMDA receptor current and persistent sodium current, and inhibit the TNF-α level, the IL-1β production, and cysteine-aspartic acid protease (caspase)-1 activity.
Source
Molecular Weight 780.98
Formula C42H68O13
CAS No. 20736-09-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (64.02 mM)

Ethanol: 30 mg/mL

H2O: Insoluble

TargetMolReferences and Literature

1. Zhao H, et al. Exp Ther Med. 2015 Aug;10(2):823-827. 2. Wu SJ, et al. Curcumin or saikosaponin a improves hepatic antioxidant capacity and protects against CCl4-induced liver injury in rats. J Med Food. 2008 Jun;11(2):224-9. 3. Yoon SS, et al. Effect of saikosaponin A on maintenance of intravenous morphine self-administration. Neurosci Lett. 2012 Oct 31;529(1):97-101. 4. Wu SJ, et al. Curcumin and saikosaponin a inhibit chemical-induced liver inflammation and fibrosis in rats. Am J Chin Med. 2010;38(1):99-111.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Lung Cancer Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library NF-κB Signaling Compound Library Anti-Fibrosis Compound Library Anti-Infection Compound Library Selected Plant-Sourced Compound Library Anti-Tumor Natural Product Library NO PAINS Compound Library

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Keywords

Saikosaponin A 20736-09-8 Metabolism Microbiology/Virology NF-Κb NF-κB Liver X Receptor Antibacterial inhibit LXR Inhibitor Liver X receptor Bacterial inhibitor

 

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