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Sempervirine

Catalog No. TN2202 CAS 6882-99-1

Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .

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Sempervirine, CAS 6882-99-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 208.00
5 mg	In stock	$ 520.00
10 mg	In stock	$ 753.00
25 mg	In stock	$ 1,160.00
50 mg	In stock	$ 1,570.00

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Purity: 98.81%

Biological Description

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Description	Sempervirine can unwind circular DNA, it shows selective inhibition of in vitro synthesis of cancer DNA .
In vitro	The high template in vitro activity of native DNA from cancerous mammalian and plant tissues, compared to DNA from healthy tissues, enabled us to select substances which selectively inhibit cancer DNA synthesis. Among them, alstonine, serpentine, Sempervirine and flavopereirine, all alkaloids which belong to the Beta-carboline class, distinguish cancer DNA from healthy tissue DNA inhibit DNA in vitro synthesis when native DNA from different cancerous tissues or cells is used as template. They have practically no effect on DNA from healthy tissues. The inhibitory effect of alkaloids is due to their capacity to form an 'alkaloid-cancer DNA' complex which has been characterized by use of the Sephadex column.
Source	Natural Products > Loganiaceae > Gelsemium

Molecular Weight	273.35
Formula	C19H17N2
CAS No.	6882-99-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.67 mg/mL (6.12 mM), Sonification is recommended

References and Literature

1. Selective inhibition of in vitro synthesis of cancer DNA by alkaloids of beta-carboline class.Exp Cell Biol. 1982;50(2):79-87.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compounds Library Max Natural Product Library for HTS RO5 Drug-like Natural Product Library Anti-Tumor Natural Product Library Alkaloid Natural Product Library DNA Damage & Repair Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

UNC9512 TK216 GS-441524 Dithranol AVG-233 T4 RNA ligase Rimantadine hydrochloride Horminone

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Keywords

Sempervirine 6882-99-1 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor inhibit

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