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Shepherdin 79-87 acetate

Catalog No. T12896L
Synonyms: Shepherdin 79-87 acetate (861224-28-4 free base)

Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Shepherdin 79-87 acetate Chemical Structure
Shepherdin 79-87 acetate, CAS N/A
Pack Size Availability Price/USD Quantity
1 mg In stock $ 148.00
5 mg In stock $ 336.00
10 mg In stock $ 497.00
25 mg In stock $ 793.00
50 mg In stock $ 1,130.00
100 mg In stock $ 1,520.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Shepherdin 79-87 acetate is a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability.
In vitro When added to prostate carcinoma (PC3, DU145) or HeLa cells, shepherdin caused concentration-dependent and complete loss of cell viability[1].
In vivo Shepherdin-RV (50 mg/kg, i.p., daily) nearly completely ablated tumor growth in immunocompromised mice prostating carcinoma PC3 cells. In a breast cancer xenograft model that employs MCF-7 cells adapted in vivo, injection of Shepherdin-RV resulted in exponentially growing tumors independently of estrogen supplementation, which was unaffected by saline administration. Shepherdin-RV (50 mg/kg i.p. daily) uniformly inhibited the growth of these more aggressive tumors (p = 0.01) throughout a 23-day or 11-day treatment regimen. Shepherdin treatment resulted in nearly complete loss of Akt levels in tumor cells and severely attenuated expression of survivin[1].
Synonyms Shepherdin 79-87 acetate (861224-28-4 free base)
Molecular Weight 1009.14
Formula C43H68N12O14S

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Plescia J, et al. Rational design of shepherdin, a novel anticancer agent. Cancer Cell. 2005 May;7(5):457-68.

Related compound libraries

This product is contained In the following compound libraries:
Peptide Compound Library Inhibitor Library Metabolism Compound Library Anti-Breast Cancer Compound Library

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Related compounds with same targets
Sepantronium bromide LQZ-7I LQZ-7F GDP366 Cucurbitacin IIA FL118

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Keywords

Shepherdin 79-87 acetate Apoptosis Cytoskeletal Signaling Metabolism HSP Survivin 861224-28-4 Shepherdin 79-87 acetate (861224-28-4 free base) Shepherdin 79-87 Acetate Shepherdin 79 87 acetate 861224-28-4 free base Shepherdin 7987 acetate inhibitor inhibit

 

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