Shopping Cart
- Remove All
Your shopping cart is currently empty
Skp2 Inhibitor C1
Catalog No. T4253Cas No. 432001-69-9
Alias SKPin C1
Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.
Skp2 Inhibitor C1
Catalog No. T4253Alias SKPin C1Cas No. 432001-69-9
Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $36 | In Stock | |
| 5 mg | $84 | In Stock | |
| 10 mg | $137 | In Stock | |
| 25 mg | $293 | In Stock | |
| 50 mg | $490 | In Stock | |
| 100 mg | $715 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $86 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Skp2 Inhibitor C1"
Indole-3-carbinol
Indole-3-Methanol, I3C, 3-Indolemethanol
T2947700-06-1
Indole-3-carbinol (I3C), a naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, inhibits NF-κB and IκBα kinase activation.
- $29
Size
QTY
NSC232003
T122611905453-18-0
NSC232003 is a highly potent and cell-permeable inhibitor of [UHRF1].
- $90
Size
QTY
Nutlin-3
Cited
Nutlin3
T2158548472-68-0
Nutlin-3 is an MDM2 antagonist that inhibits MDM2-p53 interaction (Ki=90 nM) and activates p53. Nutlin-3 binds preferentially to the p53-binding pocket of MDM2, leading to stabilization of p53 and activation of the p53 pathway. Nutlin-3 has antitumor activity.
- $54
Size
QTY
CitedNAcM-OPT
T53742089293-61-6
NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).
- $43
Size
QTY
NAE-IN-M22 Cited
NEDD8 inhibitor M22
T8816864420-54-2
NAE-IN-M22 (NEDD8 inhibitor M22) is a selective, potent and reversible inhibitor of NEDD8 activating enzyme (NAE). NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo.
- $93
Size
QTY
CitedPYZD-4409
T16699423148-78-1
PYZD-4409 is a selective UBA1 inhibitor with an IC50 of 20 μM. PYZD-4409 induces cell death in malignant cells and is preferentially cytotoxic to malignant cells over normal hematopoietic cells.
- $32
Size
QTY
Idasanutlin Cited
Ro 5503781, RG7388
T62541229705-06-9
Idasanutlin (Ro 5503781) (RG-7388) is an effective and specific p53-MDM2 inhibitor (IC50: 6 nM).
- $34
Size
QTY
CitedNSC697923
2-[(4-methylphenyl)sulfonyl]-5-nitrofuran
T6611343351-67-7In house
NSC-697923 (2-[(4-methylphenyl)sulfonyl]-5-nitrofuran), a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), exhibits its role in inducing cell death in neuroblastoma (NB) cells through two distinct mechanisms. In p53 wild-type NB cells, NSC-697923 promotes the nuclear importation of p53, thereby triggering cell death. Meanwhile, in p53 mutant NB cells, NSC-697923 activates the JNK-mediated apoptotic pathway, leading to cell death. Additionally, NSC-697923 inhibits DNA damage and NF-κB signaling, further contributing to its antitumor activity.
- $39
Size
QTY
PYR-41 Cited
PYR41, PYR 41
T6629418805-02-4
PYR-41 is the first cell-permeable inhibitor of ubiquitin-activating enzyme E1, with no activity at E2.
- $33
Size
QTY
CitedRG7112
RO5045337, RG-7112, RG 7112
T6965939981-39-2
RG7112 (RO5045337) (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
- $41
Size
QTY
Navtemadlin
CS-1300, AMG232
TQ01271352066-68-2
Navtemadlin (AMG232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction (IC50: 0.6 nM). It binds to MDM2 with a Kd of 0.045 nM.
- $67
Size
QTY
BC-1382
T85641013753-99-5
BC-1382 is a potent ubiquitin E3 ligase HECTD2 inhibitor that specifically disrupts the HECTD2/PIAS1 interaction(IC50 of 5 nM).
- $91
Size
QTY
Select Batch
Purity:100%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Skp2 Inhibitor C1 (SKPin C1)(SKPin C1) is a specific small molecule inhibitor of Skp2-mediated p27 degradation. |
| In vitro | in vitro: T47D cells treated with C1 (5 μM for 16 hours) displayed an increase in G1 phase (p < 0.0001) and a decrease in S phase (p < 0.0001), correlating with p27 protein induction. In contrast, MCF-7 cells responded to C1 with a significant reduction in G1 phase (35%, p < 0.0001) and an increase in G2-M phase (43%, p < 0.0001). This G1 reduction and G2/M arrest is dose dependent on C1 and correlates with increased p27 protein levels. |
| Kinase Assay | To test enzyme activity of NOS, the lysate from RAW264.7 cells (a protein concentration of 37.5 μg/200 μL) is incubated for 3 h at 37°C with 100 mM of L-arginine in the presence of Esonarimod (KE-298) and the conversion of L-arginine to nitrite is monitored. |
| Alias | SKPin C1 |
| Molecular Weight | 465.34 |
| Formula | C18H13BrN2O4S2 |
| Cas No. | 432001-69-9 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (107.45 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy Skp2 Inhibitor C1 | purchase Skp2 Inhibitor C1 | Skp2 Inhibitor C1 cost | order Skp2 Inhibitor C1 | Skp2 Inhibitor C1 chemical structure | Skp2 Inhibitor C1 in vitro | Skp2 Inhibitor C1 formula | Skp2 Inhibitor C1 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.