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Substance P(1-7)

Catalog No. T7396   CAS 68060-49-1
Synonyms: Substance P 1-7

Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects

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Substance P(1-7) Chemical Structure
Substance P(1-7), CAS 68060-49-1
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Substance P(1-7) (Substance P 1-7) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects
In vivo Substance P 1-7, SP(1-7), which is the main SP fragment in rat CNS, was injected intranigrally. SP(1-7) was found to act as a very potent antagonist against the SP-induced responses and was formed locally in the nigra after SP injection. It is proposed that SP(1-7) is an endogenous modulator of SP actions. Generation of peptide fragments, which retain receptor affinity but not efficacy, may be a general mechanism for autoregulation in peptidergic systems[1].
Synonyms Substance P 1-7
Molecular Weight 900.04
Formula C41H65N13O10
CAS No. 68060-49-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Herrera-Marschitz M , Terenius L , Sakurada T , et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain[J]. Brain Research, 1990, 521(1-2):316-320. 2. Skogh A , Lesniak A , Gaugaz F Z , et al. Impact of N -methylation of the substance P 1–7 amide on anti-allodynic effect in mice after peripheral administration[J]. European Journal of Pharmaceutical Sciences, 2017, 109.

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Keywords

Substance P(1-7) 68060-49-1 GPCR/G Protein Neuroscience Others Neurokinin receptor Substance P(1 7) Inhibitor Substance P Tachykinin receptor Substance P 1-7 inhibit NK receptor Neurokinin Receptor Substance P(17) inhibitor

 

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