Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. .
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 248.00 | |
50 mg | In stock | $ 373.00 | |
100 mg | In stock | $ 556.00 | |
500 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | TEPP-46 (ML265) is a potent PKM2 activator (AC50 : 92 nM) showing little or no effect on PKM1, PKL and PKR,induces tetramerization and reduces tumor formation and size in a mouse xenograft model. . |
In vivo | At 50 mg/kg, ML-265 has been shown to reduce tumor size, weight, and occurrence in mice bearing H1299 cell xenografts in a model of human non-small cell lung carcinoma[1] |
Synonyms | ML265 |
Molecular Weight | 372.46 |
Formula | C17H16N4O2S2 |
CAS No. | 1221186-53-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (134.24 mM)
You can also refer to dose conversion for different animals. More
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TEPP-46 1221186-53-3 Metabolism PKM TEPP46 Pyruvate Kinase TEPP 46 Inhibitor ML265 inhibit ML 265 ML-265 inhibitor