Powder: -20°C for 3 years | In solvent: -80°C for 1 year
THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 48.00 | |
2 mg | In stock | $ 67.00 | |
5 mg | In stock | $ 98.00 | |
10 mg | In stock | $ 189.00 | |
25 mg | In stock | $ 393.00 | |
50 mg | In stock | $ 596.00 | |
100 mg | In stock | $ 893.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 136.00 |
Description | THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively). |
Targets&IC50 | hMC4R:1.2 nM , rMC4R:0.6 nM |
In vitro | THIQ,?a small molecule agonist of the MC4R, on the cell surface expression and signaling of ten intracellularly retained MC4R mutants using different cell lines.?THIQ increased the cell surface expression of three mutants (N62S, C84R, and C271Y) and two of them (N62S and C84R) had increased signaling in HEK293 cells.THIQ increased the signaling of two other mutants (P78L and P260Q) without increasing their cell surface expression in HEK293 cells.?In neuronal cells, THIQ exhibited a more potent effect, correcting the cell surface expression and signaling of seven mutants (N62S, I69R, P78L, C84R, W174C, P260Q, and C271Y). |
Molecular Weight | 589.17 |
Formula | C33H41ClN6O2 |
CAS No. | 312637-48-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 245 mg/ml(415.84 mM), sonification is recommended.
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
THIQ 312637-48-2 GPCR/G Protein Neuroscience Melanocortin Receptor mutant MC Receptor inhibit melanocortin affinity activity erectile selective eliciting Inhibitor inhibitor