Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 126.00 | |
25 mg | In stock | $ 217.00 | |
50 mg | In stock | $ 343.00 | |
100 mg | In stock | $ 571.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 88.00 |
Description | TRPM8 antagonist 2 is a potent and selective TRPM8 antagonist with an IC50 of 0.2 nM. TRPM8 antagonist 2 is used in the research of neuropathic pain syndromes. |
Targets&IC50 | TRPM8:0.2 nM |
In vitro | TRPM8 antagonist 2 (Compound 14) is a potent and selective TRPM8 antagonist, with an IC50 of 0.2 nM, used in the research of neuropathic pain syndromes. TRPM8 antagonist 2 potently inhibits menthol-induced increase in intracellular Ca2+ levels in Ca2+ fluorimetric assays in HEK293 cells stably expressing the rat isoform of TRPM8 channels (IC50, 40 nM). |
In vivo | TRPM8 antagonist 2 (1, 10, and 30 mg/kg, s.c.) exhibits a marked, dose-dependent antinociceptive activity, and inhibits wet-dog shakes (WDS)-like cold hypersensitivity in mice by 63% at 30 mg/kg. Moreover, TRPM8 antagonist 2 (0.1 and 1 μg, s.c.) attenuates Oxaliplatin (OXP)-induced cold allodynia in mice. |
Molecular Weight | 398.5 |
Formula | C26H26N2O2 |
CAS No. | 259674-19-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 160 mg/mL (401.51 mM)
You can also refer to dose conversion for different animals. More
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TRPM8 antagonist 2 259674-19-6 Membrane transporter/Ion channel TRP/TRPV Channel inhibit Transient receptor potential channels TRP Channel Inhibitor TRPM-8 antagonist 2 inhibitor