Home Tools

Tanshinone IIA sulfonate sodium

Catalog No. T2946 CAS 69659-80-9

Synonyms: Tanshinone IIA sulfonate, Sodium Tanshinone IIA sulfonate, Tanshinone IIA sodium sulfonate, sodium

Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor P2X7. Tanshinone IIA sulfonate sodium (12.5 μM) inhibits hypoxia-induced PKG and PPAR-γ downregulation in PASMCs and distal pulmonary arteries of rats.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Tanshinone IIA sulfonate sodium Chemical Structure

Tanshinone IIA sulfonate sodium, CAS 69659-80-9

Pack Size	Availability	Price/USD
10 mg	In stock	$ 39.00
25 mg	In stock	$ 64.00
50 mg	In stock	$ 93.00
100 mg	In stock	$ 137.00
500 mg	In stock	$ 342.00

Bulk Inquiry

Select Batch

Purity: 99.9%

Purity: 99.04%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor P2X7. Tanshinone IIA sulfonate sodium (12.5 μM) inhibits hypoxia-induced PKG and PPAR-γ downregulation in PASMCs and distal pulmonary arteries of rats.
Targets&IC50	CYP3A4:6.377 μM
In vitro	Sodium Tanshinone IIA sulfonate (12.5 μM) effectively inhibits hypoxia-induced downregulation of PKG and PPAR-γ in PASMCs and the distal pulmonary arteries of rats, indicating its role in preserving pulmonary vascular function. This compound also prevents the reduction of TRPC1 and TRPC6 expression in hypoxic PASMCs, a process that is reversible upon specific knockdown of PKG or PPAR-γ. This suggests the involvement of the PKG-PPAR-γ signaling axis in mitigating the proliferative response of PASMCs under hypoxic conditions. Furthermore, a PPAR-γ agonist enhances the compound's ability to maintain basal calcium levels and store-operated calcium entry (SOCE) in PASMCs. In terms of drug metabolism, Sodium Tanshinone IIA sulfonate dose-dependently inhibits CYP3A4 activity in human liver microsomes (HLMs) and CYP3A4 isoform, with minimal impact on other CYP enzymes, suggesting a specific interaction with the CYP3A4 pathway. The kinetic parameters for its inhibition of CYP3A4 are detailed for both HLMs and the CYP3A4 isoform. Due to its significant inhibitory effect on CYP3A4, Sodium Tanshinone IIA sulfonate has the potential for drug-drug interactions when administered with other CYP3A4 substrates.
In vivo	Sodium Tanshinone IIA sulfonate administered at dosages of 10 mg/kg and 20 mg/kg, in conjunction with Donepezil, effectively reduces escape latency, enhances the number of times subjects crossed the original platform location, and extends the duration spent in the target quadrant in experimental settings. This compound notably diminishes acetylcholinesterase (AChE) activity while boosting choline acetyltransferase (ChAT) activity within the hippocampus and cortex of SCOP-treated mice, alongside increasing superoxide dismutase (SOD) activity and reducing malondialdehyde (MDA) and reactive oxygen species (ROS) levels in the same regions. At a preventive dosage of 30 mg/kg/day, Sodium Tanshinone IIA sulfonate mitigates the characteristic alterations induced by hypoxia in a chronic hypoxia PH rat model. Moreover, when administered intraperitoneally at dosages of 20, 10, and 5 mg/kg, it effectively prevents peritoneal adhesion without impeding anastomotic healing in rats, demonstrating increased peritoneal lavage fluid tPA activity and tPA/PAI-1 ratio, alongside decreased TGF-β1 and collagen I expressions in ischemic tissues.
Source	Natural Products > Lamiaceae > Salvia

Synonyms	Tanshinone IIA sulfonate, Sodium Tanshinone IIA sulfonate, Tanshinone IIA sodium sulfonate, sodium
Molecular Weight	396.39
Formula	C19H17O6S·Na
CAS No.	69659-80-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (126.14 mM), The compound is unstable in solution. Please use soon.

References and Literature

1. Xu QQ, et al. Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic System. Biomed Res Int. 2016;22016:19852536. 2. Jiang, Q., Lu, W., Yang, K., Hadadi, C., Fu, X., & Chen, Y. et al. (2016). Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-γ signaling axis. American Journal Of Physiology-Cell Physiology, 311(1), C136-C149. doi: 10.1152/ajpcell.00252.2015 3. Ouyang DS, et al. Kinetics of cytochrome P450 enzymes for metabolism of sodium tanshinone IIA sulfonate in vitro. Chin Med. 2016 Mar 22;11:11. 4. Chen D, et al. Sodium tanshinone IIA sulfonate and its interactions with human CYP450s. Xenobiotica. 2016 Dec;46(12):1085-1092. Epub 2016 Mar 2. 5. Lin S, et al. [Sodium tanshinone IIA sulfonate prevents postoperative peritoneal adhesions in rats by enhancing the activity of the peritoneal fibrinolytic system]. Nan Fang Yi Ke Da Xue Xue Bao. 2016 Feb;36(2):260-4.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Inhibitor Library Anti-Cancer Clinical Compound Library Kinase Inhibitor Library FDA-Approved Kinase Inhibitor Library Drug Repurposing Compound Library Ion Channel Inhibitor Library Neuronal Signaling Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

W-9 hydrochloride KN-92 phosphate Y-33075 dihydrochloride Rottlerin CaM kinase II inhibitor TFA salt STO-609 Elziverine CaMKII-IN-1

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

Dosage

mg/kg

Average weight of animals

Dosing volume per animal

Number of animals

Step Two: Enter the in vivo formulation

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

Calculate Reset

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

Calculator

Molarity Calculator

Dilution Calculator

Reconstitution Calculation

Molecular Weight Calculator

Mass

Concentration

Volume

Molecular Weight

Molarity Calculator allows you to calculate the

Mass of a compound required to prepare a solution of known volume and concentration
Volume of solution required to dissolve a compound of known mass to a desired concentration
Concentration of a solution resulting from a known mass of compound in a specific volume

See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

Concentration (Start)

Volume (Start)

Concentration (End)

Volume (End)

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Molecule Formula

Molecular Weight g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tanshinone IIA sulfonate sodium 69659-80-9 Membrane transporter/Ion channel Metabolism Neuroscience Calcium Channel P450 CaMK CRAC Channel Calcium release-activated channels Tanshinone IIA sulfonate Sodium Tanshinone IIA sulfonate Ca2+ release-activated Ca2+ channels Tanshinone IIA sodium sulfonate inhibit Inhibitor sodium inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.