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VPC171

Catalog No. T29112 CAS 1018830-99-3

Synonyms: VPC-171, VPC 171

VPC171 is a novel adenosine A1 receptor positive allosteric modulator (PAM).

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VPC171, CAS 1018830-99-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	VPC171 is a novel adenosine A1 receptor positive allosteric modulator (PAM).
In vivo	VCP171 produced a greater inhibition of eEPSC amplitude of nerve-injury versus control animals in both lamina I and lamina II neurons[2].

Synonyms	VPC-171, VPC 171
Molecular Weight	347.35
Formula	C18H12F3NOS
CAS No.	1018830-99-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 20 mg/ml(57.58 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Aurelio L, et al. Allosteric modulators of the adenosine A1 receptor: synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes. J Med Chem. 2009 Jul 23;52(14):4543-7. 2. Imlach WL, et al. A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model. Mol Pharmacol. 2015 Sep;88(3):460-8.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

VPC171 1018830-99-3 GPCR/G Protein Neuroscience Adenosine Receptor VCP171 Lamina II VPC-171 AMPAR Sprague-Dawley rats P1 receptor VPC 171 neuropathic pain VCP-171 inhibit Inhibitor A1R VCP 171 neurons inhibitor

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