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Vitamin K1

Catalog No. T1075 CAS 84-80-0

Synonyms: Phylloquinone, Phytomenadione, Phytonadione, Phyllohydroquinone

Vitamin K1 (Phylloquinone) a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity.

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Vitamin K1, CAS 84-80-0

Pack Size	Availability	Price/USD
1 g	In stock	$ 37.00
5 g	In stock	$ 97.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 99.82%

Purity: 99.53%

Purity: 98.11%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Vitamin K1 (Phylloquinone) a fat-soluble, naturally occurring vitamin with antihemorrhagic and prothrombogenic activity.
In vitro	Phylloquinone, also known as vitamin K1, is a vital compound produced solely by plants, green algae, and some cyanobacteria. It functions importantly in photosynthesis as an electron carrier in photosystem I and aids in forming protein disulfide bonds. Beyond its plant-based roles, phylloquinone is crucial for blood coagulation, bone, and vascular health in humans and other vertebrates, with green leafy vegetables and vegetable oil being its primary dietary sources[1]. Therapeutically, vitamin K1 exhibits a notable antiproliferative effect and induces apoptosis in specific cancer cell lines such as Caco-2, HT-29, and SW480, likely through the MAPK pathway, while also significantly reducing polyamine biosynthesis[2].
In vivo	Subjects who augmented their dietary vitamin K intake during the follow-up exhibited a 51% lower risk of developing diabetes compared to those who reduced or maintained their phylloquinone (vitamin K) consumption [3]. Furthermore, vitamin K supplementation countered bone deterioration in mice on a high-fat diet by modulating osteoblast and osteoclast activities, thereby preventing bone loss [4]. Additionally, topical application of vitamin K1 on skin has been effective in reducing pigmentation and resolving bruising, demonstrating significant improvement in wound healing, epithelialization time, hydroxyproline content, and tensile strength when compared to the control group [5].
Cell Research	Caco-2, HT-29, and SW480 cells are treated with increasing concentrations of vitamin K1 (10, 50, 100, and 200 μM) for 24 h, 48 h, and 72 h. MTT is added to each dish and incubated for 2 h at 37°C. At the end of the incubation period, the medium is removed. The plate is read at 570 nM[2].

Synonyms	Phylloquinone, Phytomenadione, Phytonadione, Phyllohydroquinone
Molecular Weight	450.7
Formula	C31H46O2
CAS No.	84-80-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 25 mg/mL (55.47 mM)

References and Literature

1. Basset GJ, et al. Phylloquinone (Vitamin K1): Occurrence, Biosynthesis and Functions. Mini Rev Med Chem. 2016 Jun 22. 2. Orlando A, et al. Vitamin K1 exerts antiproliferative effects and induces apoptosis in three differently graded human colon cancer cell lines. Biomed Res Int. 2015;22015:296721. 3. Ibarrola-Jurado N, et al. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012 Nov;96(5):1113-8. 4. Kim M, et al. Vitamin K1 (phylloquinone) and K2 (menaquinone-4) supplementation improves bone formation in a high-fat diet-induced obese mice. J Clin Biochem Nutr. 2013 Sep;53(2):108-13. 5. Hemmati AA, et al. Topical vitamin K1 promotes repair of full thickness wound in rat. Indian J Pharmacol. 2014 Jul-Aug;46(4):409-12.

Citations

1. Li Y, Xing Z, Wang S, et al.Disruption of biofilms in periodontal disease through the induction of phase transition by cationic dextrans.Acta Biomaterialia.2023

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Tobacco Monomer Library Chinese Pharmacopoeia Natural Product Library Coagulation and Anticoagulation Compound Library Orally Active Compound Library Traditional Chinese Medicine Monomer Library ReFRAME Related Library Bioactive Compound Library Natural Product Library for HTS Gut Microbial Metabolite Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Vitamin K1 84-80-0 Metabolism Others Endogenous Metabolite Vitamin K-1 Phylloquinone inhibit Vitamin K 1 Phytomenadione Phytonadione Inhibitor Phyllohydroquinone inhibitor

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