Powder: -20°C for 3 years | In solvent: -80°C for 1 year
WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 38.00 | |
2 mg | In stock | $ 53.00 | |
5 mg | In stock | $ 89.00 | |
10 mg | In stock | $ 147.00 | |
25 mg | In stock | $ 297.00 | |
50 mg | In stock | $ 588.00 | |
100 mg | In stock | $ 839.00 | |
500 mg | In stock | $ 1,720.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 98.00 |
Description | WS-383 is a selective, potent and reversible DCN1-UBC12 interaction inhibitor(IC50 of 11 nM). |
Targets&IC50 | DCN1-UBC12:11 nM |
In vitro | WS-383 (10 μM) is selective to the DCN1–UBC12 interaction over the selected kinasesr. WS-383 (0.03-3 μM;24 hours) blocks Cul3 neddylation at 3 μM and also has certain inhibition of Cul1 neddylation at 10 μM but was not effective in inhibiting neddylation of other cullin members. WS-383 (0.03-3 μM;24 hours) increases Cul1, Skp1 (adaptor protein), F-box protein, and RBX1/RBX2 RING protein form SCF E3 complex. Cyclin dependent kinase inhibitor 1A (p21) and cyclin dependent kinase inhibitor 1B (p27) expression in a dose-dependent manner in MGC-803 and KYSE70 manner. |
Molecular Weight | 498.46 |
Formula | C18H21Cl2N9S2 |
CAS No. | 2247544-02-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 7.35 mg/mL (14.75 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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WS-383 2247544-02-9 Ubiquitination E1/E2/E3 Enzyme Ubiquitin conjugating enzyme DCN1-UBC12 E1 activating enzyme E3 ligating enzyme interaction KYSE70 WS 383 E2 conjugating enzyme cell Ubiquitin ligase MGC-803 Inhibitor WS383 Ubiquitin activating enzyme inhibit inhibitor