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Wy 49051

Catalog No. T13352Cas No. 113418-56-7
Alias Wy-49051

Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).

Wy 49051

Wy 49051

Purity: 97.9%
Catalog No. T13352Alias Wy-49051Cas No. 113418-56-7
Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).
Pack SizePriceAvailabilityQuantity
1 mg$152In Stock
5 mg$298In Stock
10 mg$433In Stock
25 mg$678In Stock
50 mg$912In Stock
100 mg$1,180In Stock
200 mg$1,580In Stock
1 mL x 10 mM (in DMSO)$395In Stock
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Purity:97.9%
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Product Introduction

Bioactivity
Description
Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).
Targets&IC50
H1 receptor:44 nM
In vitro
Wy 49051 showed a great inhibitory effect on H1. At a concentration of 100 nM, it produced 92% inhibition of histamine-induced guinea pig ileal contraction. Wy 49051 is the most effective compound, with 700 times the potency of astemizole and 470 times the potency of hydroquinone. Wy 49051 also has high affinity for α1 receptor with IC50 of 8 nM[1].
In vivo
Wy 49051 demonstrates efficacy in counteracting histamine-induced lethality in guinea pigs, with effective doses (ED50) of 1.91 mg/kg orally (po), 0.70 mg/kg intraperitoneally (ip), and 0.01 mg/kg intravenously (iv). Additionally, the compound maintains its oral efficacy without any reduction for up to 18 hours posttreatment[1].
AliasWy-49051
Chemical Properties
Molecular Weight487.59
FormulaC28H33N5O3
Cas No.113418-56-7
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (92.29 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0509 mL10.2545 mL20.5090 mL102.5452 mL
5 mM0.4102 mL2.0509 mL4.1018 mL20.5090 mL
10 mM0.2051 mL1.0255 mL2.0509 mL10.2545 mL
20 mM0.1025 mL0.5127 mL1.0255 mL5.1273 mL
50 mM0.0410 mL0.2051 mL0.4102 mL2.0509 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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