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Wy 49051
Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).
Catalog No. T13352Cas No. 113418-56-7
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Purity:97.9%
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Wy 49051
Catalog No. T13352Alias Wy-49051Cas No. 113418-56-7
Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $152 | In Stock | |
| 5 mg | $298 | In Stock | |
| 10 mg | $433 | In Stock | |
| 25 mg | $678 | In Stock | |
| 50 mg | $912 | In Stock | |
| 100 mg | $1,180 | In Stock | |
| 200 mg | $1,580 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $395 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Wy 49051 is an orally active antagonist of H1 receptor(IC50 of 44 nM). |
| Targets&IC50 | H1 receptor:44 nM |
| In vitro | Wy 49051 showed a great inhibitory effect on H1. At a concentration of 100 nM, it produced 92% inhibition of histamine-induced guinea pig ileal contraction. Wy 49051 is the most effective compound, with 700 times the potency of astemizole and 470 times the potency of hydroquinone. Wy 49051 also has high affinity for α1 receptor with IC50 of 8 nM[1]. |
| In vivo | Wy 49051 demonstrates efficacy in counteracting histamine-induced lethality in guinea pigs, with effective doses (ED50) of 1.91 mg/kg orally (po), 0.70 mg/kg intraperitoneally (ip), and 0.01 mg/kg intravenously (iv). Additionally, the compound maintains its oral efficacy without any reduction for up to 18 hours posttreatment[1]. |
| Alias | Wy-49051 |
| Molecular Weight | 487.59 |
| Formula | C28H33N5O3 |
| Cas No. | 113418-56-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (92.29 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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