Shopping Cart
- Remove All
Your shopping cart is currently empty
YTX-465
Catalog No. T9722Cas No. 2225824-53-1
YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).
YTX-465
Catalog No. T9722Cas No. 2225824-53-1
YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $176 | In Stock | |
| 5 mg | $373 | In Stock | |
| 10 mg | $590 | In Stock | |
| 25 mg | $876 | In Stock | |
| 50 mg | $1,180 | In Stock | |
| 100 mg | $1,590 | In Stock | |
| 200 mg | $2,130 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $428 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "YTX-465"
SLC13A5-IN-1
T129312227548-95-8
SLC13A5-IN-1 is a selective inhibitor of the sodium-citrate co-transporter (SLC13A5) that completely blocks the uptake of 14C-citrate, with an IC50 of 0.022 μM in HepG2 cells.
- $43
Size
QTY
SCD1 inhibitor-4
T105251295541-87-5
SCD1 inhibitor-4 is stearoylCoA desaturase-1 (SCD1) inhibitor. SCD1 inhibitor-4 can be used for the research of diabetes.
- $38
Size
QTY
A939572
Cited
T45151032229-33-6
A939572 is stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM for mSCD1 and 37 nM for hSCD1.
- $39
Size
QTY
CitedGSK1940029
SCD inhibitor 1
T54271150701-66-8In house
GSK1940029 (SCD inhibitor 1) is an inhibitor of stearoyl-CoA desaturase (SCD).
- $30
Size
QTY
Elemicin Cited
Elemicine, 3,4,5-trimethoxyallylbenzene
T3341487-11-6
Elemicin (Elemicine) is a constituent of several plant species' essential oils with anticholinergic effects in human.
- $41
Size
QTY
CitedPluriSIn 1 Cited
PluriSln 1, PluriSIn #1, NSC 14613
T186991396-88-2
PluriSIn 1 (NSC 14613) is an inhibitor of stearoyl-CoA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, highlighting a unique role for lipid metabolism in hPSCs.
- $31
Size
QTY
CitedCAY10566
T14878944808-88-2
CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl
- $47
Size
QTY
MF-438
T16068921605-87-0
MF-438 is an effective and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor (EC50: 2.3 nM for rSCD1).
- $98
Size
QTY
XEN723
T133561072803-08-7
XEN723 is a potent thiazolylimidazolidinone Stearoyl-CoA Desaturase (SCD1) inhibitor(IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively).
- $50
Size
QTY
CVT-12012
T64121018675-35-8
CVT-12012 is an orally bioavailable inhibitor of stearoyl-CoA desaturase (SCD; IC50 = 6.1 nM in HepG2 cells).
- $34
Size
QTY
MK-8245
T26501030612-90-8
MK-8245 is a liver-targeting SCD inhibitor for human SCD1 (IC50: 1 nM) and for rat/mouse SCD1 (IC50: 3 nM), with anti-diabetic and anti-dyslipidemic function.
- $33
Size
QTY
SSI-4
T792621875084-68-6
SSI-4 is a Stearoyl CoA desaturase 1 (SCD1) inhibitor that can be labeled with carbon-11 (11C) for use as a ligand in small animal in vivo PET/CT imaging studies of SCD1 [1].
- $1,520
Size
QTY
Select Batch
Purity:99.41%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | YTX-465 is an inhibitor of both stearoyl-CoA desaturase(IC50s = 39 nM) and Ole1 (IC50s = 30.4 μM). |
| Targets&IC50 | Ole1:39 nM, SCD:30.4 μM |
| In vitro | YTX-465 rescued growth to a similar magnitude but was >100-fold more potent than YTX-528(EC50 = 0.013 μM). Kinetic growth studies demonstrated that the most effective concentration of YTX-465 (0.050 μM) restored growth rates to that of approximately 40% of the wild-type strain treated with the same concentration of YTX-465[1]. In wild-type yeast, YTX-465 strongly reduced fatty desaturation in a concentration-dependent manner, with a 50% reduction in desaturation at 0.03 μM YTX-465[1]. |
| Molecular Weight | 458.51 |
| Formula | C25H26N6O3 |
| Cas No. | 2225824-53-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (109.05 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy YTX-465 | purchase YTX-465 | YTX-465 cost | order YTX-465 | YTX-465 chemical structure | YTX-465 in vitro | YTX-465 formula | YTX-465 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.