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CAY10566
🥰Excellent
Catalog No. T14878Cas No. 944808-88-2
CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively..
CAY10566
🥰Excellent
Purity: 99.54%
Catalog No. T14878Cas No. 944808-88-2
CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50s of 4.5 and 26 nM in mouse and human enzymatic assays, respectively..
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 44 € | In Stock | |
| 5 mg | 147 € | In Stock | |
| 10 mg | 227 € | In Stock | |
| 25 mg | 463 € | In Stock | |
| 50 mg | 680 € | In Stock | |
| 100 mg | 937 € | In Stock | |
| 500 mg | 1.871 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 126 € | In Stock |
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Purity:99.54%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CAY10566 shows excellent cellular activity in blocking the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50=7.9 nM or 6.8 nM). CAY10566 is a potent, orally bioavailable and selective stearoyl |
| Targets&IC50 | SCD1 (mouse):4.5 nM (IC50), SCD1 (human):26 nM (IC50) |
| In vitro | CAY10566 (0.0001-10 μM; 24 hours) concentration-dependently decreases Swiss 3T3 cell proliferation [3]. |
| In vivo | Upon the formation of detectable tumors, mice receive either a placebo or the SCD1 inhibitor CAY10566 (2.5 mg/kg orally twice daily). SCD1 inhibition demonstrates a more pronounced effect on Akt-driven tumors compared to Ras-driven tumors. Specifically, the average tumor volume on days 13 or 14 after treatment, compared to control tumors, was 0.5±0.04 for Akt-driven tumors and 0.67±0.05 for Ras-driven tumors (P=0.01 for Ras-Akt comparison, according to a two-tailed t-test) [4]. |
| Molecular Weight | 389.81 |
| Formula | C18H17ClFN5O2 |
| Cas No. | 944808-88-2 |
| Smiles | Cc1nnc(o1)-c1ccc(nn1)N1CCC(CC1)Oc1cc(F)ccc1Cl |
| Relative Density. | 1.369 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 24 mg/mL (61.57 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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