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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $66 | In Stock | |
10 mg | $103 | In Stock | |
25 mg | $249 | In Stock | |
50 mg | $426 | In Stock | |
1 mL x 10 mM (in DMSO) | $66 | In Stock |
Description | ZM323881 hydrochloride (ZM 323881 HCl) is a potent and selective VEGFR2 inhibitor. |
Targets&IC50 | VEGFR2:<2 nM |
In vivo | At concentrations below 1 μM, ZM323881 inhibits the proliferation of neural stem cells stimulated by VEGF in a dose-dependent manner. It impedes the activation of extracellular signal-regulated kinase, p38, Akt, and endothelial nitric oxide synthase (eNOS) through VEGF blockade at 1 μM, without suppressing the expression of the VEGFR-1 specific ligand, placental growth factor (PlGF), in human aortic endothelial cells (HAECs). Additionally, 1 μM ZM323881 disrupts VEGF-induced membrane extension, cell migration, and tube formation in HAECs and reverses the phosphorylation of CrkII and its SRC homology 2 domain-binding protein p130Cas, key in regulating endothelial cell migration. ZM323881 inhibits the proliferation of HUVEC cells induced by VEGF-A, EGF, and bFGF, with IC50 values of 8 nM, 1.9 μM, and 1.6 μM respectively. At 10 nM, ZM323881 eradicates the increase in vascular permeability mediated by VEGF-A in the mesenteric microvasculature of male leopards. Furthermore, 10 nM ZM323881 completely obstructs VEGF-induced promoter activity and Hif-1α protein accumulation in VEGF-stimulated SCC-9 cells. |
Alias | ZM 323881 hydrochloride, ZM 323881 HCl |
Molecular Weight | 411.86 |
Formula | C22H19ClFN3O2 |
Cas No. | 193000-39-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (97.12 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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