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A-77636
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Catalog No. T78644Cas No. 778546-51-3
A-77636 is a potent, selective, and long-acting oral dopamine D1 receptor agonist with an effective concentration (EC50) of 1.1 nM and a corresponding pEC50 value of 8.13. It demonstrates the highest affinity for the dopamine D1 receptor with a dissociation constant (Ki) of 39.8 nM and a pKi of 7.40 ± 0.09. Notably, A-77636 exhibits antiparkinsonian activity [1].
A-77636
😃Good
Catalog No. T78644Cas No. 778546-51-3
A-77636 is a potent, selective, and long-acting oral dopamine D1 receptor agonist with an effective concentration (EC50) of 1.1 nM and a corresponding pEC50 value of 8.13. It demonstrates the highest affinity for the dopamine D1 receptor with a dissociation constant (Ki) of 39.8 nM and a pKi of 7.40 ± 0.09. Notably, A-77636 exhibits antiparkinsonian activity [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | 1.444 € | 6-8 weeks | |
| 50 mg | 1.881 € | 6-8 weeks | |
| 100 mg | 2.375 € | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | A-77636 is a potent, selective, and long-acting oral dopamine D1 receptor agonist with an effective concentration (EC50) of 1.1 nM and a corresponding pEC50 value of 8.13. It demonstrates the highest affinity for the dopamine D1 receptor with a dissociation constant (Ki) of 39.8 nM and a pKi of 7.40 ± 0.09. Notably, A-77636 exhibits antiparkinsonian activity [1]. |
| Targets&IC50 | D1 receptor:1.1 nM (EC50), D1 receptor:39.8 nM (Ki) |
| In vivo | A-77636 (0-3.2 μmol/kg, subcutaneous injection) induced rotational behavior in rats with 6-OHDA lesions (ED50 = 0.32 μmol/kg sc) [1], attenuated drug-induced locomotor activity in a dose-dependent manner (1-10 mg/kg) [2], and elicited forelimb clonus in rats (ED50 = 12.3 μmol/kg s.c.) and mice (ED50 = 12.1 μmol/kg s.c.) [1]. In MPTP-treated marmosets, A-77636 (0.5, 1.0, or 2.0 μmol/kg, oral administration) increased motor activity and reduced Parkinsonian symptoms, demonstrating efficacy with both subcutaneous and oral administration [1]. |
| Molecular Weight | 329.43 |
| Formula | C20H27NO3 |
| Cas No. | 778546-51-3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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