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ABT-670
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Catalog No. T14088Cas No. 630119-43-6
ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.
ABT-670
😃Good
Catalog No. T14088Cas No. 630119-43-6
ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 8-10 weeks | |
| 50 mg | $1,980 | 8-10 weeks | |
| 100 mg | $2,500 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ABT-670 is a selective agonist of dopamine D4 receptor. For human D4, ferret D4, and rat D4, the EC50 values are 89 nM, 160 nM, and 93 nM , respectively. |
| Targets&IC50 | D4 (rat):93 nM（EC50）, D4 (Ferret):160 nM（EC50）, D4 (human):（EC50）89 nM |
| In vitro | ABT-670 is a selective D4 agonist. For human?D4, ferret?D4, and rat?D4, the EC50s values are 89 nM, 160 nM, and 93 nM, respectively[1]. |
| In vivo | ABT-670, at a dosage of 0.1 μmol/kg, significantly promotes a high incidence (75%) of erections in male rats, demonstrating robust efficacy. Furthermore, it displays exceptional oral bioavailability across multiple species—rat (68%), dog (85%), and monkey (91%)—while maintaining comparable efficacy, safety, and tolerability[1]. |
| Molecular Weight | 325.4 |
| Formula | C19H23N3O2 |
| Cas No. | 630119-43-6 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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