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Acetazolamide

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Catalog No. T0813Cas No. 59-66-5
Alias Diamox

Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.

Acetazolamide

Acetazolamide

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Purity: 99.83%
Catalog No. T0813Alias DiamoxCas No. 59-66-5
Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.
Pack SizePriceAvailabilityQuantity
100 mg$35 Backorder
200 mg$42 Backorder
500 mg$50 Backorder
1 g$53 Backorder
1 mL x 10 mM (in DMSO)$48 Backorder
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Purity:99.83%
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Product Introduction

Bioactivity
Description
Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.
Targets&IC50
CA:10 nM
In vitro
acetazolamide reduces invasiveness of cancer cells in vitro[3].
In vivo
Acetazolamide reduces inflammation-induced heat hyperalgesia, probably acting both peripherally and centrally[1]. Acetazolamide shows significant inhibitory effect on angiogenesis in CAM and endothelial cell proliferation[2]. Acetazolamide is clinically used to reduce intraocular pressure in glaucoma, to correct metabolic alkalosis, and to manage cerebral edema. Its treatment may also be beneficial as an adjunct to cancer chemotherapy, because it can produce additive tumor growth delays with anticancer drugs in vivo[3].
Cell Research
The invasion assay is performed in a Biocoat Matrigel invasion chamber. Cells (n = 1.8 × 105) are added to the chamber and cultured for 48 h in the presence or absence of acetazolamide, which was administered twice during the 48-h period: the first dose at the beginning of the assay and the second after 24 h. After growing for 48 h, noninvasive cells are removed from the upper surface of the membrane with a cotton swab. The invasive cells on the lower surface of the membrane are fixed with 4% (vol/vol) neutral-buffered formaldehyde, stained with toluidine blue, and counted in 20 separate areas with a Leitz Diaplan microscope. (Only for Reference)
AliasDiamox
Chemical Properties
Molecular Weight222.245
FormulaC4H6N4O3S2
Cas No.59-66-5
SmilesCC(=O)NC1=NN=C(S1)S(N)(=O)=O
Relative Density.1.610 g/cm3 (Estimated)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: <1 mg/mL
DMSO: >10 mM, Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.4995 mL22.4977 mL44.9954 mL224.9769 mL
5 mM0.8999 mL4.4995 mL8.9991 mL44.9954 mL
10 mM0.4500 mL2.2498 mL4.4995 mL22.4977 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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