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Product Introduction

Bioactivity

Description	Alendronic Acid (alendronate) is a nonhormonal medication used for osteoporosis, osteogenesis imperfecta, and several other bone diseases.
In vivo	Alendronic Acid in the treatment of osteoporosis in children and adolescents[1].
Alias	alendronate

Chemical Properties

Molecular Weight	249.1
Formula	C₄H₁₃NO₇P₂
Cas No.	66376-36-1
Smiles	NCCCC(O)(P(O)(O)=O)P(O)(O)=O
Relative Density.	1.857 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: < 1 mg/mL (insoluble）

H2O: 6.56 mg/mL (26.33 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	4.0145 mL	20.0723 mL	40.1445 mL	200.7226 mL
5 mM	0.8029 mL	4.0145 mL	8.0289 mL	40.1445 mL
10 mM	0.4014 mL	2.0072 mL	4.0145 mL	20.0723 mL
20 mM	0.2007 mL	1.0036 mL	2.0072 mL	10.0361 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

turnoverosteoporosisInhibitorinhibithealingFDPSbonebisphosphonatesAlendronic Acid