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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
5 mg | $88 | In Stock | |
10 mg | $122 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $297 | In Stock | |
100 mg | $453 | In Stock | |
500 mg | $987 | In Stock | |
1 mL x 10 mM (in DMSO) | $97 | In Stock |
Description | ALOIN Inhibits Interleukin (IL)-1β-Stimulated IL-8 Production in KB Cells. |
In vitro | Clostridium histolyticum collagenase (ChC) results dose-dependently inhibited by aloe gel and the activity-guided fractionation led to an active fraction enriched in phenolics and aloins.?Aloins have been shown to be able to bind and to inhibit ChC reversibly and non-competitively.?Aloe gel and aloins are also effective inhibitors of stimulated granulocyte matrix metalloproteinases (MMPs)[1]. |
In vivo | Aloin effectively inhibits salivary IL-1β-induced IL-8 production by mitigating the p38 and ERK pathway. Therefore, aloin may be a good candidate for modulating oral inflammatory diseases[2]. |
Animal Research | Saliva was collected from volunteers to determine IL-1β and IL-8 levels. Samples from volunteers were divided into two groups: those with low and those with high IL-1β levels. KB cells were stimulated with IL-1β or saliva with or without IL-1 receptor agonist or specific mitogen-activated protein kinase (MAPK) inhibitors. IL-8 production was measured by enzyme-linked immunosorbent assay (ELISA). MAPK protein expression involved in IL-1β-induced IL-8 secretion was detected by Western blot. KB cells were pretreated with?aloin, and its effect on IL-1β-induced IL-8 production was examined by ELISA and Western blot analysis[1]. |
Cas No. | 8015-61-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: 50 mg/mL (119.51 mM) ![]() |
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