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AMG 579
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Purity:99.35%
AMG 579
Catalog No. T14217Cas No. 1227067-61-9
AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 2 mg | $39 | In Stock | |
| 5 mg | $67 | In Stock | |
| 10 mg | $107 | In Stock | |
| 25 mg | Inquiry | In Stock | |
| 50 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $75 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM). |
| Targets&IC50 | PDE10A:0.1 nM |
| In vivo | AMG 579 statistically reduces PCP-induced behavior in rats within 2 hours. In the PCP-LMA model, the minimum effective dose of AMG 579 was 0.3 mg/kg. AMG 579 has an excellent oral bioavailability of 72% in dogs[1]. |
| Alias | AMG-579 |
| Molecular Weight | 441.48 |
| Formula | C25H23N5O3 |
| Cas No. | 1227067-61-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 37.8 mg/mL (85.6 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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