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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $30 | In Stock | |
2 mg | $39 | In Stock | |
5 mg | $67 | In Stock | |
10 mg | $107 | In Stock | |
25 mg | Inquiry | In Stock | |
50 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | $75 | In Stock |
Description | AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM). |
Targets&IC50 | PDE10A:0.1 nM |
In vivo | AMG 579 statistically reduces PCP-induced behavior in rats within 2 hours. In the PCP-LMA model, the minimum effective dose of AMG 579 was 0.3 mg/kg. AMG 579 has an excellent oral bioavailability of 72% in dogs[1]. |
Alias | AMG-579 |
Molecular Weight | 441.48 |
Formula | C25H23N5O3 |
Cas No. | 1227067-61-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 37.8 mg/mL (85.6 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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