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Antileishmanial agent-16
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Catalog No. T78963Cas No. 2934738-41-5
Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and amastigotes (IC50 = 0.81 µM), while maintaining a favorable safety profile in mammalian cells (VERO cells) [1].
Antileishmanial agent-16
😃Good
Catalog No. T78963Cas No. 2934738-41-5
Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and amastigotes (IC50 = 0.81 µM), while maintaining a favorable safety profile in mammalian cells (VERO cells) [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 8-10 weeks | |
| 50 mg | $1,980 | 8-10 weeks | |
| 100 mg | $2,500 | 8-10 weeks |
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Chemical Properties
| Description | Antileishmanial agent-16 (compound 14c), an anti-Leishmania agent, exhibits potent activity against Leishmania major promastigotes (IC50 = 0.59 µM) and amastigotes (IC50 = 0.81 µM), while maintaining a favorable safety profile in mammalian cells (VERO cells) [1]. |
| In vitro | Antileishmanial agent-16 administered at 0-20 µM for 24 hours exhibits potent anti-promastigote and amastigote activities against L. major with respective IC 50 values of 0.59 µM and 0.81 µM [1]. The compound demonstrates high selectivity towards L. amastigote and safety towards mammalian cells (VERO cells), as evidenced by a selectivity index (SI) of 311.4 [1]. The SI is the ratio of in vitro cytotoxicity (CC 50 in µM) to the antileishmanial activity against amastigotes (IC 50 in µM). |
| Molecular Weight | 495.61 |
| Formula | C27H37N5O4 |
| Cas No. | 2934738-41-5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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