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Antitrypanosomal agent 12, a C20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with GI50 values of 0.22 μM. It induces faster cell swelling in bloodstream-form trypanosomes compared to Salinomycin [1].
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50 mg | Inquiry | Backorder |
Description | Antitrypanosomal agent 12, a C20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with GI50 values of 0.22 μM. It induces faster cell swelling in bloodstream-form trypanosomes compared to Salinomycin [1]. |
In vitro | Antitrypanosomal agent 12 at 100 mM for 60 minutes induced cellular swelling in the bloodstream form of T. brucei more rapidly than Salinomycin [1]. Additionally, agent 12 showed greater selectivity for T. brucei over HL-60 cells, with MIC values of 1 μM (T. brucei) and 10 μM (HL-60 cells) [1]. |
Molecular Weight | 909.2 |
Formula | C49H77N2NaO10S |
Storage | Shipping with blue ice. |
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