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Antitrypanosomal agent 12

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Catalog No. T78977

Antitrypanosomal agent 12, a C20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with GI50 values of 0.22 μM. It induces faster cell swelling in bloodstream-form trypanosomes compared to Salinomycin [1].

Antitrypanosomal agent 12

Antitrypanosomal agent 12

😃Good
Catalog No. T78977
Antitrypanosomal agent 12, a C20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with GI50 values of 0.22 μM. It induces faster cell swelling in bloodstream-form trypanosomes compared to Salinomycin [1].
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Product Introduction

Bioactivity
Description
Antitrypanosomal agent 12, a C20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with GI50 values of 0.22 μM. It induces faster cell swelling in bloodstream-form trypanosomes compared to Salinomycin [1].
In vitro
Antitrypanosomal agent 12 at 100 mM for 60 minutes induced cellular swelling in the bloodstream form of T. brucei more rapidly than Salinomycin [1]. Additionally, agent 12 showed greater selectivity for T. brucei over HL-60 cells, with MIC values of 1 μM (T. brucei) and 10 μM (HL-60 cells) [1].
Chemical Properties
Molecular Weight909.2
FormulaC49H77N2NaO10S
Storage & Solubility Information
StorageShipping with blue ice.

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