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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | Antitrypanosomal agent 12, a C20-phenylthiourea, exhibits trypanocidal and cytotoxic activities, demonstrating antitrypanosomal activity with GI50 values of 0.22 μM. It induces faster cell swelling in bloodstream-form trypanosomes compared to Salinomycin [1]. |
In vitro | Antitrypanosomal agent 12 (化合物 4d) at a concentration of 100 mM for 60 minutes exhibited more rapid induction of cellular swelling in the bloodstream form of T. brucei than the natural compound Salinomycin [1]. Furthermore, agent 12 demonstrated superior selectivity towards T. brucei over HL-60 cells, with respective MIC values of 1 μM (T. brucei) and 10 μM (HL-60 cells) [1]. |
Molecular Weight | 909.2 |
Formula | C49H77N2NaO10S |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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