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Apoptosis inducer 30

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Catalog No. T201277

Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.

Apoptosis inducer 30

Apoptosis inducer 30

😃Good
Catalog No. T201277
Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.
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Product Introduction

Bioactivity
Description
Apoptosisinducer 30 (Compound 15a) acts as an anticancer agent. It induces apoptosis in MCF-7 cells through the mitochondrial pathway. This compound elevates intracellular levels of reactive oxygen species (ROS), decreases mitochondrial membrane potential, and arrests the cell cycle at the G0/G1 phase. Apoptosisinducer 30 inhibits cell growth, with an IC50 value of 0.32 μM against MCF-7 cells, and suppresses tumor growth in a mouse breast cancer model.
In vitro
Apoptosis Inducer 30 effectively inhibits the growth of tumor cells, exhibiting IC 50 values of 1.01 μM for A549, 0.91 μM for HepG2, 0.32 μM for MCF-7, 0.95 μM for HeLa, and 8.09 μM for MCF-10A cells. At concentrations ranging from 100 to 500 nM over 48 hours, Apoptosis Inducer 30 elevates the cytochrome C (Cyt-C) levels in MCF-7 cells and activates caspase-9 and caspase-7.
Chemical Properties
Molecular Weight882.99
FormulaC52H69BrNO4P
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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