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Asundexian (BAY-2433334) is a potent and orally active inhibitor of the coagulation factor FXIa that directly and reversibly binds to the active site of FXIa, thereby inhibiting its activity.Asundexian has an IC50 of 1 nM for human FXIa in buffer.Asundexian has antitumor activity and may be useful in studies of Acute ischemic stroke, transient ischemic attack and ischemic stroke.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $304 | In Stock | |
5 mg | $729 | In Stock | |
10 mg | $1,310 | In Stock | |
25 mg | $2,500 | In Stock | |
50 mg | $4,820 | In Stock | |
100 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | $899 | In Stock |
Description | Asundexian (BAY-2433334) is a potent and orally active inhibitor of the coagulation factor FXIa that directly and reversibly binds to the active site of FXIa, thereby inhibiting its activity.Asundexian has an IC50 of 1 nM for human FXIa in buffer.Asundexian has antitumor activity and may be useful in studies of Acute ischemic stroke, transient ischemic attack and ischemic stroke. |
Targets&IC50 | FXIa (human):1 nM |
In vivo | Asundexian displays potent anticoagulant activity in vitro in human and rabbit plasma and antithrombotic efficacy in vivo in a rabbit arterial thrombosis model.[1] |
Alias | BAY-2433334, BAY2433334, BAY 2433334, Asundexian |
Molecular Weight | 592.93 |
Formula | C26H21ClF4N6O4 |
Cas No. | 2064121-65-7 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 118.59 mg/mL (200.01 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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