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Atropine sulfate monohydrate

Catalog No. T0375LCas No. 5908-99-6
Alias Atropine sulfate hydrate

Atropine sulfate monohydrate (Atropine sulfate hydrate), the sulfate salt of atropine, is a competitive muscarinic acetylcholine receptor antagonist.

Atropine sulfate monohydrate

Atropine sulfate monohydrate

Purity: 98.05%
Catalog No. T0375LAlias Atropine sulfate hydrateCas No. 5908-99-6
Atropine sulfate monohydrate (Atropine sulfate hydrate), the sulfate salt of atropine, is a competitive muscarinic acetylcholine receptor antagonist.
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Purity:98.05%
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Product Introduction

Bioactivity
Description
Atropine sulfate monohydrate (Atropine sulfate hydrate), the sulfate salt of atropine, is a competitive muscarinic acetylcholine receptor antagonist.
Targets&IC50
mAChR:2.5 nM
In vitro
Atropine increases the release of the neurotransmitter dopamine into the superfusate in vitro at 100-500 mM and into the vitreous in vivo at 250 mg. Atropine induces spreading depression (SD) in the in vitro preparation. Atropine reduces the ERG b- and d-wave, leads to damped oscillations of RPE potentials, and reverses the ERG c-wave. Atropine suppresses myopia only at doses at which severe nonspecific side effects are observed in the retina. [1]
In vivo
Atropine (1.0 mg/kg, i.p.), but not methylatropine (1.0 mg/kg, i.p.), prevents the enhancement of retention induced by both doses of the anticholinesterase when given immediately after training in mice. [2] Atropine administration effectively prevents bradycardia and second-degree heart block but induces pulsus alternans and hypertension in dogs. [3] Atropine has no effect on handling-induced acetylcholine output in the presence of 10 nM neostigmine, but causes greater and longer increases in the presence of 100 nM and 1000 nM neostigmine in rats. [4] Atropine not only blocks the rapid eye movement (REM) sleep increases induced by CGS but it also tends to decrease REM sleep compared to atropine preceding saline in rats. [5] Atropine decreases the time to exhaustion by 67% in intact rats and by 96.2% in adrenodemedullated (ADM) and also reduces the exercise-induced pituitary prolactin (PRL) release in both intact (50%) and ADM rats (90%). [6]
AliasAtropine sulfate hydrate
Chemical Properties
Molecular Weight694.83
FormulaC34H46N2O6·H2SO4·H2O
Cas No.5908-99-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 128 mg/mL (184.2 mM)
Ethanol: 128 mg/mL (184.2 mM)
H2O: 127 mg/mL (182.8 mM)
Solution Preparation Table
H2O/DMSO/Ethanol
1mg5mg10mg50mg
1 mM1.4392 mL7.1960 mL14.3920 mL71.9600 mL
5 mM0.2878 mL1.4392 mL2.8784 mL14.3920 mL
10 mM0.1439 mL0.7196 mL1.4392 mL7.1960 mL
20 mM0.0720 mL0.3598 mL0.7196 mL3.5980 mL
50 mM0.0288 mL0.1439 mL0.2878 mL1.4392 mL
100 mM0.0144 mL0.0720 mL0.1439 mL0.7196 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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