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AWL-II-38.3
AWL-II-38.3 is a highly potent EphA3 inhibitor with potent kinase inhibitory activity against EphA3 but no significant cellular activity against Src family kinases or b-raf.
Catalog No. T38511Cas No. 1135205-94-5
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Purity:99.87%
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AWL-II-38.3
Catalog No. T38511Cas No. 1135205-94-5
AWL-II-38.3 is a highly potent EphA3 inhibitor with potent kinase inhibitory activity against EphA3 but no significant cellular activity against Src family kinases or b-raf.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $74 | In Stock | |
| 5 mg | $178 | In Stock | |
| 10 mg | $278 | In Stock | |
| 25 mg | $572 | In Stock | |
| 50 mg | $822 | In Stock | |
| 100 mg | $1,130 | In Stock | |
| 500 mg | $2,280 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $186 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AWL-II-38.3 is a highly potent EphA3 inhibitor with potent kinase inhibitory activity against EphA3 but no significant cellular activity against Src family kinases or b-raf. |
| In vitro | The structure of AWL-II-38.3 fits into the ATP-binding and substrate-binding pockets of LIMK2 and LIMK1[1]；ALW-II-38.3 forms four direct hydrogen bonds between the ATP-binding cleft of EphA3: the first between the inhibitor oxazole N and the backbone NH of the hinge residue Met702, and the second between the oxazole amide NH and the gatekeeper Thr699 between the side chain hydroxyl group, the third between the benzamide carbonyl oxygen and the main chain NH of Asp764 of the "DFG-motif", the fourth between the inhibitor benzamide NH and the side chain carboxylate necessary for catalysis Glu670 is located in the αC-helix.[2] |
| Molecular Weight | 469.42 |
| Formula | C23H18F3N5O3 |
| Cas No. | 1135205-94-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (95.86 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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