Shopping Cart
- Remove All
Your shopping cart is currently empty
BI 224436
😃Good
Catalog No. T14559Cas No. 1155419-89-8
BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.
BI 224436
😃Good
Catalog No. T14559Cas No. 1155419-89-8
BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $5,130 | 10-14 weeks | |
| 5 mg | $9,870 | 10-14 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "BI 224436"
Dextran sulfate sodium salt (MW 4500-5500)
Cited
DSS, Dextran sulfate sodium salt (MW 4500-5500)
T136479011-18-1
Dextran sulfate sodium salt (MW 4500-5500) is an anhydrous glucose polymer with a molecular weight range of 4500-5500. It inhibits human immunodeficiency virus replication by preventing viral adsorption to host cells and is commonly used to model inflammatory bowel disease. The high negative charge from its sulfate groups damages the intestinal mucosal barrier, leading to intestinal barrier dysfunction, macrophage impairment, and bacterial flora disorder.
- $39
Size
QTY
CitedEmtricitabine Cited
FTC, Emtriva, BW1592
T6214143491-57-0
Emtricitabine is a nucleoside reverse transcriptase inhibitor with anti-human immunodeficiency virus (HIV) and hepatitis B virus activity, with an EC50 value of 0.01 µM in PBMC cells, and can be used to study HIV infection.
- $45
Size
QTY
CitedLamivudine Cited
GR109714X, BCH-189
T0682134678-17-4
Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.
- $53
Size
QTY
CitedStavudine
Sanilvudine, NSC 163661, d4T, BMY-27857
T14043056-17-5
Stavudine (BMY-27857), a nucleoside reverse transcriptase inhibitor analog of thymidine, has activity against HIV.
ApoptosisAutophagyHIV ProteaseNOD-like Receptor (NLR)Nucleoside Antimetabolite/AnalogReverse Transcriptase
- $33
Size
QTY
Valproic Acid
Cited
VPA, Sodium valproate, Depakine, 2-Propylvaleric Acid, 2-Propylpentanoic Acid
T706499-66-1
Valproic Acid (2-Propylpentanoic Acid) is an HDAC inhibitor that inhibits HDAC1 activity, induces HDAC2 degradation, and is orally active. Valproic Acid can be used in epilepsy and bipolar disorder research.
- $50
Size
QTY
Cited5-Fluorouracil Cited
NSC 19893, Fluorouracil, 5-FU, 5-Fluoracil
T098451-21-8
5-Fluorouracil (5-FU) is a uracil analog and inhibitor of DNA synthesis, exhibiting antitumor activity by affecting pyrimidine synthesis through thymidylate synthase inhibition; it induces apoptosis and autophagy.
- $30
Size
QTY
CitedDecanedioic acid Cited
Sebacinsaure, Sebacic acid, 1,8-Octanedicarboxylic acid, 1,10-Decanedioic acid
T3732111-20-6
Decanedioic acid (Sebacinsaure) is a saturated, straight-chain naturally occurring dicarboxylic acid.
- $59
Size
QTY
CitedKaempferol Cited
Robigenin, Kempferol
T2177520-18-3
Kaempferol (Robigenin) is a natural flavonoid and an inverse agonist of ERRα and ERRγ. Kaempferol has a wide range of antitumor, anti-inflammatory, antioxidant, antibacterial and antiviral activities.
ApoptosisAutophagyEndogenous MetaboliteEstrogen Receptor/ERREstrogen/progestogen ReceptorHIV ProteaseMitophagyParasite
- $46
Size
QTY
CitedDimethyl fumarate Cited
DMF
T0492624-49-7
Dimethyl fumarate (DMF) is an Nrf2 activator with oral activity and blood-brain barrier permeability. Dimethyl fumarate has antimicrobial, anti-inflammatory, and immunomodulatory activities and has been used in the study of multiple sclerosis.
- $45
Size
QTY
CitedTenofovir Cited
TDF, PMPA, GS 1278
T1649147127-20-6
Tenofovir (GS 1278) is an adenine analog REVERSE TRANSC-RIPTASE INHIBITOR with antiviral activity against HIV-1 and HEPATITIS B. It is used to treat HIV INFECTIONS and CHRONIC HEPATITIS B, in combination with other ANTIVIRAL AGENTS, due to the emergence of ANTIVIRAL DRUG RESISTANCE when it is used alone.
- $37
Size
QTY
CitedDolutegravir intermediate-1
1-(2,2-dimethoxyethyl)-5-methoxy-6-methoxycarbonyl-4-oxopyridine-3-carboxylic acid, 1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid
T110741335210-23-5
Dolutegravir intermediate-1 (1-(2,2-dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-carboxylic acid) is a new synthetic Dolutegravir intermediate. Dolutegravir is an integrase inhibitor developed for the treatment of human immunodeficiency virus (HIV)-1 infection.
- $29
Size
QTY
Chloroquine phosphate Cited
Chloroquine diphosphate, Chingamin phosphate, Aralen phosphate
T019450-63-5
Chloroquine phosphate (Aralen phosphate) is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
- $42
Size
QTY
CitedContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | BI 224436 is an inhibitor of HIV-1 noncatalytic site integrase. With EC50 values of less than 15 nM against different HIV-1 laboratory strains. |
| Targets&IC50 | HIV-1:（EC50）15 nM |
| In vitro | BI 224436 exhibits over 90 μM cellular cytotoxicity and retains its antiviral efficacy with a minimal 2.1-fold reduction in the presence of 50% human serum. It possesses favorable in vitro drug-like absorption, distribution, metabolism, and excretion (ADME) characteristics, such as Caco-2 cell permeability, solubility, and minimal cytochrome P450 inhibition[1]. Moreover, BI 224436 maintains complete antiviral functionality against recombinant viruses bearing integrase strand transfer inhibitor (INSTI) resistance mutations, namely N155S, Q148H, and E92Q. Additionally, it demonstrates an additive effect when used alongside most approved antiretrovirals, including INSTIs. |
| In vivo | BI 224436 demonstrates favorable pharmacokinetic properties across multiple species, including rats, monkeys, and dogs. Specifically, in rats, the compound has a clearance rate of 0.7% as a percentage of hepatic flow and a bioavailability of 54%. In monkeys, the clearance rate is 23% with an 82% bioavailability, while in dogs, the clearance is 8%, with bioavailability reaching 81%[1]. |
| Molecular Weight | 442.51 |
| Formula | C27H26N2O4 |
| Cas No. | 1155419-89-8 |
| Relative Density. | 1.277 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (112.99 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy BI 224436 | purchase BI 224436 | BI 224436 cost | order BI 224436 | BI 224436 chemical structure | BI 224436 in vivo | BI 224436 in vitro | BI 224436 formula | BI 224436 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.