Shopping Cart
- Remove All
Your shopping cart is currently empty
Argentina
Australia
Austria
Belgium
Brazil
Bulgaria
Croatia
Cyprus
Czech
Denmark
Egypt
Estonia
Finland
France
Germany
Greece
Hong Kong
Hungary
Iceland
India
Ireland
Israel
Italy
Japan
Korea
Latvia
Lebanon
Malaysia
Malta
Morocco
Netherlands
New Zealand
Norway
Poland
Portugal
Romania
Singapore
Slovakia
Slovenia
Spain
Sweden
Switzerland
Taiwan,China
Thailand
Turkey
United Kingdom
United States
Other Countries
Select your Country or Region
BI-0474
Catalog No. T69529Cas No. 2750570-55-7
BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G12C mutation, and shows significant anti-tumor activity in a non-small cell lung cancer xenograft model. activity.BI-0474 can be used for cancer research.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $388 | In Stock | |
| 5 mg | $818 | In Stock | |
| 10 mg | $1,230 | In Stock | |
| 25 mg | $1,980 | In Stock | |
| 50 mg | $2,730 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $778 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "BI-0474"
6H05
T19311469338-01-9
6H05 (K-Ras inhibitor) is a selective, allosteric inhibitor of oncogenic mutant K-Ras(G12C).
- $129
Size
QTY
SOS1/KRAS-IN-1
T791622836330-34-6
SOS1/KRAS-IN-1 (Compound 2) serves as an inhibitor of SOS1/KRAS, with potential application in the study of diseases mediated by SOS1/KRAS [1].
- $1,970
Size
QTY
RMC-7977
T812632765082-12-8
RMC-7977 is a highly selective inhibitor of the active (GTP-bound) forms of KRAS, HRAS, and NRAS with anticancer activity for the study of solid tumors with KRAS G12C mutations.
- $810
Size
QTY
ARS-1323
T103751698024-73-5
ARS-1323 is the racemate of ARS-1620 and a mutant K-ras G12C inhibitor.
- $60
Size
QTY
6H05 (TFA)
T73262061344-88-3
6H05 TFA (6H05 trifluoroacetate) is a selective, and allosteric oncogenic mutant K-Ras(G12C) inhibitor.
- $63
Size
QTY
KRAS G12C inhibitor 5
T117802158297-63-1
KRAS G12C inhibitor 5 is a KRas G12C inhibitor.
- $2,120
Size
QTY
PROTAC K-Ras Degrader-1
T138442378258-52-5
PROTAC K-Ras Degrader-1 is potent degrader of K-Ras based PROTAC.
- $456
Size
QTY
KRas G12C inhibitor 4
T117792206736-07-2
KRas G12C inhibitor 4 is a compound that inhibits KRas G12C.
- $1,520
Size
QTY
Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BI-0474 is a potent KRASG12C inhibitor that inhibits GDP-KRAS::SOS1 protein-protein interactions with an IC50 value of 7.0 nM.BI-0474 exhibits significant antiproliferative activity against NCI-H358 cells harboring the G12C mutation, and shows significant anti-tumor activity in a non-small cell lung cancer xenograft model. activity.BI-0474 can be used for cancer research. |
| In vitro | BI-0474 (1-10,000 nM; 3 days; NCI-H358 cells carrying a G12C mutation) inhibited proliferation of NCI-H358 cells with an EC50 of 26 nM.[1] |
| In vivo | BI-0474 (40 mg/kg; i.p.; single daily for 3 days; NMRI nude mice) shows anti-tumor efficacy and pharmacodynamic biomarker modulation. This led to the induction of programmed cell death in this xenograft model.[1] |
| Molecular Weight | 587.74 |
| Formula | C30H37N9O2S |
| Cas No. | 2750570-55-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。 Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Dose Conversion
You can also refer to dose conversion for different animals. More
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.