Shopping Cart

Remove All

Your shopping cart is currently empty

BIP-135

Select Batch

Purity:99.77%

Resource Download

COA HNMR CNMR HPLC

BIP-135

Catalog No. T14613Cas No. 941575-71-9

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$51	In Stock
2 mg	$74	In Stock
5 mg	$122	In Stock
10 mg	$197	In Stock
25 mg	$389	In Stock
50 mg	$579	In Stock
100 mg	$828	In Stock
500 mg	$1,680	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "BIP-135"

Product Introduction

Bioactivity

Description	BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].
In vitro	BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress[1]. BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations[1].
In vivo	BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy. And it does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)[1].

Chemical Properties

Molecular Weight	421.24
Formula	C21H13BrN2O3
Cas No.	941575-71-9

Storage & Solubility Information

Storage

keep away from direct sunlight|Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 56.7 mg/mL (134.6 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3739 mL	11.8697 mL	23.7394 mL	118.6972 mL
5 mM	0.4748 mL	2.3739 mL	4.7479 mL	23.7394 mL
10 mM	0.2374 mL	1.1870 mL	2.3739 mL	11.8697 mL
20 mM	0.1187 mL	0.5935 mL	1.1870 mL	5.9349 mL
50 mM	0.0475 mL	0.2374 mL	0.4748 mL	2.3739 mL
100 mM	0.0237 mL	0.1187 mL	0.2374 mL	1.1870 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc