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Bithionol sulfoxide

Name: Bithionol sulfoxide
Brand: TargetMol
SKU: T10551
Price: 217 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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Catalog No. T10551Cas No. 844-26-8

Bithionol sulfoxide is a clinically approved antiparasitic drug with the inhibitory against solid tumor growth in several preclinical cancer models.

Bithionol sulfoxide

😃Good

Catalog No. T10551Cas No. 844-26-8

Bithionol sulfoxide is a clinically approved antiparasitic drug with the inhibitory against solid tumor growth in several preclinical cancer models.

Pack Size	Price	Availability
25 mg	Inquiry	6-8 weeks
50 mg	Inquiry	6-8 weeks
100 mg	Inquiry	6-8 weeks

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Resource Download

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description

Bithionol sulfoxide is a clinically approved antiparasitic drug with the inhibitory against solid tumor growth in several preclinical cancer models.

In vitro

Bithionol caused dose-dependent cytotoxicity against all ovarian cancer cell lines tested (IC50s: 19 μM - 60 μM). BT treatment resulted in cell cycle arrest at the G1/M phase and increased ROS generation [1]. Both bithionol and bithionol sulphoxide demonstrated in vitro toxicity to Neoparamoeba spp. at all concentrations examined (0.1 to 10 mg/l over 72 h), with comparable toxicity to freshwater observed for both chemicals at concentrations > 5 mg/l following a 72 h treatment [2].

Chemical Properties

Molecular Weight	372.05
Formula	C₁₂H₆Cl₄O₃S
Cas No.	844-26-8
Relative Density.	1.86 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (671.95 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6878 mL	13.4391 mL	26.8781 mL	134.3905 mL
5 mM	0.5376 mL	2.6878 mL	5.3756 mL	26.8781 mL
10 mM	0.2688 mL	1.3439 mL	2.6878 mL	13.4391 mL
20 mM	0.1344 mL	0.6720 mL	1.3439 mL	6.7195 mL
50 mM	0.0538 mL	0.2688 mL	0.5376 mL	2.6878 mL
100 mM	0.0269 mL	0.1344 mL	0.2688 mL	1.3439 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Bithionol sulfoxide