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BRD0639
🥰Excellent
Catalog No. T9329Cas No. 2760881-74-9
BRD0639 is a pioneering inhibitor targeting the interaction between PRMT5 and its substrate adaptor. As a competitive inhibitor of the PRMT5 binding motif (PBM), BRD0639 facilitates the investigation of activities dependent on PBM-associated PRMT5 functions [1].
BRD0639
🥰Excellent
Purity: 99.85%
Catalog No. T9329Cas No. 2760881-74-9
BRD0639 is a pioneering inhibitor targeting the interaction between PRMT5 and its substrate adaptor. As a competitive inhibitor of the PRMT5 binding motif (PBM), BRD0639 facilitates the investigation of activities dependent on PBM-associated PRMT5 functions [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 48 € | In Stock | |
| 5 mg | 115 € | In Stock | |
| 10 mg | 188 € | In Stock | |
| 25 mg | 392 € | In Stock | |
| 50 mg | 534 € | In Stock | |
| 100 mg | 748 € | In Stock | |
| 1 mL x 10 mM (in DMSO) | 126 € | In Stock |
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Purity:99.85%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BRD0639 is a pioneering inhibitor targeting the interaction between PRMT5 and its substrate adaptor. As a competitive inhibitor of the PRMT5 binding motif (PBM), BRD0639 facilitates the investigation of activities dependent on PBM-associated PRMT5 functions [1]. |
| In vitro | BRD0639, a pioneering PBM-competitive small molecule, facilitates the research of PBM-dependent PRMT5 activities and aids in developing specific PRMT5 inhibitors. It effectively binds to the cellular target, efficiently inhibiting the interaction between full-length PRMT5 and RIOK1 proteins with IC50 values of 7.5 uM and 16 uM in permeabilized and living cells, respectively. Moreover, BRD0639 decreases SDMA levels in proteins impacted by genetic alterations of the PRMT5 binding motif (PBM) site [1]. |
| Molecular Weight | 475.95 |
| Formula | C21H22ClN5O4S |
| Cas No. | 2760881-74-9 |
| Smiles | S(NCCC1=CC=CC=N1)(=O)(=O)C2=CC(NC([C@H](C)N3C(=O)C=C(Cl)C=N3)=O)=CC=C2C |
| Relative Density. | 1.41 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 60 mg/ml (126.06 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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