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BRD4/CK2-IN-1

🥰Excellent
Catalog No. T63991Cas No. 2756851-99-5

BRD4/CK2-IN-1 is a small molecule inhibitor targeting BRD4 and CK2, with an IC50 of 180nM for BRD4 and 230nM for CK2. It inhibits the proliferation of MDA-MB-231 and MDA-MB-468 cells, inducing apoptosis and autophagy-related cell death. It can be used in triple-negative breast cancer research.

BRD4/CK2-IN-1

BRD4/CK2-IN-1

🥰Excellent
Purity: 99.02%
Catalog No. T63991Cas No. 2756851-99-5
BRD4/CK2-IN-1 is a small molecule inhibitor targeting BRD4 and CK2, with an IC50 of 180nM for BRD4 and 230nM for CK2. It inhibits the proliferation of MDA-MB-231 and MDA-MB-468 cells, inducing apoptosis and autophagy-related cell death. It can be used in triple-negative breast cancer research.
Pack SizePriceAvailabilityQuantity
1 mg$88 In Stock
5 mg$216 In Stock
10 mg$329 In Stock
25 mg$652 In Stock
50 mg$987 In Stock
100 mg$1,490 In Stock
200 mg$2,090 In Stock
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Purity:99.02%
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Product Introduction

Bioactivity
Description
BRD4/CK2-IN-1 is a small molecule inhibitor targeting BRD4 and CK2, with an IC50 of 180nM for BRD4 and 230nM for CK2. It inhibits the proliferation of MDA-MB-231 and MDA-MB-468 cells, inducing apoptosis and autophagy-related cell death. It can be used in triple-negative breast cancer research.
Targets&IC50
BRD4:180 nM, CK2:230 nM
In vitro
BRD4/CK2-IN-1 showed significant inhibitory activity against BRD4 (IC50 = 180 nM). BRD4/ CK2-in-1 showed significant inhibitory activity against CK2 (IC50 = 230 nM).
BRD4/ CK2-in-1 induces TNBC cell death by targeting BRD4 and CK2. BRD4/ CK2-in-1 can bind to BRD4 and CK2 IN cells and inhibit BRD4 and CK2-regulated proliferation pathways, but has no significant effect on the protein levels of BRD4 and CK2. [1]
In vivo
In MDA-MB-468 and MDA-MB-231 xenograft tumor models, BRD4/CK2-IN-1 (25 mg/kg and 50 mg/kg) was administered intravenously and orally to inhibit tumor growth in a dose-dependent manner. [1]
Chemical Properties
Molecular Weight564.03
FormulaC29H30ClN5O5
Cas No.2756851-99-5
SmilesO=C1N=C(NC=2C=C(OC)C=C(OC)C12)C=3C=CC(OCC(=O)NC4=CC=C(C(Cl)=C4)N5CCN(C)CC5)=CC3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 16 mg/mL (28.37 mM), when pH is adjusted to 3 with HCl, sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7730 mL8.8648 mL17.7296 mL88.6478 mL
5 mM0.3546 mL1.7730 mL3.5459 mL17.7296 mL
10 mM0.1773 mL0.8865 mL1.7730 mL8.8648 mL
20 mM0.0886 mL0.4432 mL0.8865 mL4.4324 mL

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