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Bz 423

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Purity:98.89%

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COA HNMR LCMS HPLC

Bz 423

Catalog No. T14846Cas No. 216691-95-1

Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus.

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Pack Size	Price	Availability	Quantity
2 mg	$48	5 days

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Product Introduction

Bioactivity

Description	Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus.
In vitro	Bz-423 triggers the activation of Bax and Bak without concurrently activating ASK1/JNK in Ramos cells[2]. The induction of apoptosis by Bz-423 in Ramos cells relies on superoxide, and it elicits a heightened superoxide response in these cells, resulting in the swift demise of Ramos B cells. In MEFs, Bz-423 rapidly elevates superoxide levels within 1 hour, with the extent of the increase depending on the concentration. In Ramos cells, Bz-423-induced superoxide generation instigates the activation of Bax and Bak, mediated by alterations in Mcl-1 expression and the functional activation of BH3-only proteins[1].
Alias	BZ48

Chemical Properties

Molecular Weight	440.92
Formula	C27H21ClN2O2
Cas No.	216691-95-1

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (181.44 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2680 mL	11.3399 mL	22.6799 mL	113.3993 mL
5 mM	0.4536 mL	2.2680 mL	4.5360 mL	22.6799 mL
10 mM	0.2268 mL	1.1340 mL	2.2680 mL	11.3399 mL
20 mM	0.1134 mL	0.5670 mL	1.1340 mL	5.6700 mL
50 mM	0.0454 mL	0.2268 mL	0.4536 mL	2.2680 mL
100 mM	0.0227 mL	0.1134 mL	0.2268 mL	1.1340 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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