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Cerebroside B
😃Good
Catalog No. TN1481Cas No. 88642-46-0
Cerebroside B1b has antiulcerogenic activity.
Cerebroside B
😃Good
Catalog No. TN1481Cas No. 88642-46-0
Cerebroside B1b has antiulcerogenic activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $540 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $820 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Cerebroside B1b has antiulcerogenic activity. |
| In vitro | Here, fusaruside is clarified biosynthetically, and its efficacy-related 10,11-double bond can be generated under the regioselective catalysis of an unprecedented α?10(E)-sphingolipid desaturase (α?10(E)-SD). α?10(E)-SD shares 17.7% amino acid sequence similarity with a C9-unmethylated α?10-sphingolipid desaturase derived from a marine diatom, and 55.7% with α?8(E)-SD from Fusarium graminearum. Heterologous expression of α?10(E)-SD in Pichia pastoris has been established to facilitate a reliable generation of 1 through the α?10(E)-SD catalyzed desaturation of Cerebroside B (2), an abundant fungal sphingolipid. Site directed mutageneses show that the conserved histidines of α?10(E)-SD are essential for the 10,11-desaturation catalysis, which is also preconditioned by the C9-methylation of the substrate. Moreover, α?10(E)-SD confers improved survival and faster growth to fungal strains at low temperature and high salinity, in parallel with to higher contents of 1 in the mycelia. |
| Molecular Weight | 728.065 |
| Formula | C41H77NO9 |
| Cas No. | 88642-46-0 |
| Relative Density. | 1.09 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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