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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $30 | In Stock | |
10 mg | $51 | In Stock | |
25 mg | $97 | In Stock | |
50 mg | $179 | In Stock | |
100 mg | $355 | In Stock | |
500 mg | $842 | In Stock | |
1 mL x 10 mM (in DMSO) | $39 | In Stock |
Description | CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR. |
In vivo | In senescent cells with halted proliferation, treatment with CGK733 leads to the disappearance of senescence-associated beta-galactosidase (SA-β-gal) activity, enabling the cells to proliferate. In aged MCF-7 cells, 24-hour treatment with CGK733 (30 μM) can induce cell death. Furthermore, in various cancer cells, such as MCF-7 and T47D estrogen receptor (ER) positive breast cancer cells, MDA-MB436 ER-negative breast cancer cells, LnCap precursor cancer cells, and HCT116 colon cancer cells, CGK733 (0.6-40 μM) has the capability to inhibit proliferation. |
Alias | CGK 733 |
Molecular Weight | 555.84 |
Formula | C23H18Cl3FN4O3S |
Cas No. | 905973-89-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (179.9 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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