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Ch55

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Purity:99.01%

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COA HNMR HPLC

Ch55

Catalog No. T14946Cas No. 110368-33-7

Ch55 (3,5-Di-tert-butylchalcone) is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors. Ch55 can be used in studies about cancer.

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Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$97	In Stock
10 mg	$147	In Stock
25 mg	$286	In Stock
50 mg	$522	In Stock
100 mg	$759	In Stock
500 mg	$1,580	In Stock
1 mL x 10 mM (in DMSO)	$106	In Stock

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Product Introduction

Bioactivity

Description	Ch55 (3,5-Di-tert-butylchalcone) is an effective inducer of the differentiation of HL60 cells (EC50 = 200 nM) and shows high affinity with RAR-α and RAR-β receptors. Ch55 can be used in studies about cancer.
In vitro	In rabbit tracheal epithelial cells, Ch55 inhibits type I transglutaminase activity (EC50 = 0.02 nM) and increases cholesterol sulfate levels (EC50 = 0.03 nM) thereby inhibiting squamous cell differentiation. Ch55 inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM) and induces cell differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50 = 0.26 and 0.5 nM). Ch55 shows a low affinity for cellular retinoic acid binding protein[1].
Alias	Ch-55, CH 55, 3,5-Di-tert-butylchalcone

Chemical Properties

Molecular Weight	364.48
Formula	C24H28O3
Cas No.	110368-33-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 40 mg/mL (109.7 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7436 mL	13.7182 mL	27.4363 mL	137.1817 mL
5 mM	0.5487 mL	2.7436 mL	5.4873 mL	27.4363 mL
10 mM	0.2744 mL	1.3718 mL	2.7436 mL	13.7182 mL
20 mM	0.1372 mL	0.6859 mL	1.3718 mL	6.8591 mL
50 mM	0.0549 mL	0.2744 mL	0.5487 mL	2.7436 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	1.3718 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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