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Cipepofol

Cipepofol
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Cipepofol

Catalog No. T32105Cas No. 1637741-58-2
Cipepofol (HSK3486) is a GABAA receptor agonist with sedative properties and protective effects in a variety of cardiovascular diseases.Cipepofol activates the Sirtuin1 (Sirt1)/Nrf2 pathway and induces apoptosis in cardiomyocytes, and can be used to study myocardial infarction, myocardial ischemia/reperfusion injury, and octopus pot syndrome.
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Pack SizePriceAvailabilityQuantity
1 mg$166In Stock
2 mg$243In Stock
5 mg$397In Stock
10 mg$595In Stock
25 mg$970In Stock
50 mg$1,720In Stock
100 mg$2,720In Stock
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Product Introduction

Bioactivity
Description
Cipepofol (HSK3486) is a GABAA receptor agonist with sedative properties and protective effects in a variety of cardiovascular diseases.Cipepofol activates the Sirtuin1 (Sirt1)/Nrf2 pathway and induces apoptosis in cardiomyocytes, and can be used to study myocardial infarction, myocardial ischemia/reperfusion injury, and octopus pot syndrome.
In vitro
Cipepofol (5 μM; administered before ISO injury; for 6 hours) can attenuate ISO-induced apoptosis in cultured cardiomyocytes in vitro[2].
In vivo
In eighty male C57BL/6 mice (20-24 g, 8-10 weeks old), Cipepofol (100 μl; administered into the abdomen of mice 1 hour before ISO injection) was able to attenuate the increase in serum CK-MB, LDH, and cTnT levels induced by ISO (100 mg/kg; subcutaneous injection; for 2 consecutive days) to create experimental myocardial infarction. Additionally, Cipepofol significantly improved ISO-induced left ventricular systolic and diastolic dysfunction[2].
AliasHSK3486, HSK-3486, CS-0064163, HSK 3486
Chemical Properties
Molecular Weight204.31
FormulaC14H20O
Cas No.1637741-58-2
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 80 mg/mL (391.56 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.8945 mL24.4726 mL48.9452 mL244.7262 mL
5 mM0.9789 mL4.8945 mL9.7890 mL48.9452 mL
10 mM0.4895 mL2.4473 mL4.8945 mL24.4726 mL
20 mM0.2447 mL1.2236 mL2.4473 mL12.2363 mL
50 mM0.0979 mL0.4895 mL0.9789 mL4.8945 mL
100 mM0.0489 mL0.2447 mL0.4895 mL2.4473 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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