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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $166 | In Stock | |
2 mg | $243 | In Stock | |
5 mg | $397 | In Stock | |
10 mg | $595 | In Stock | |
25 mg | $970 | In Stock | |
50 mg | $1,720 | In Stock | |
100 mg | $2,720 | In Stock |
Description | Cipepofol (HSK3486) is a GABAA receptor agonist with sedative properties and protective effects in a variety of cardiovascular diseases.Cipepofol activates the Sirtuin1 (Sirt1)/Nrf2 pathway and induces apoptosis in cardiomyocytes, and can be used to study myocardial infarction, myocardial ischemia/reperfusion injury, and octopus pot syndrome. |
In vitro | Cipepofol (5 μM; administered before ISO injury; for 6 hours) can attenuate ISO-induced apoptosis in cultured cardiomyocytes in vitro[2]. |
In vivo | In eighty male C57BL/6 mice (20-24 g, 8-10 weeks old), Cipepofol (100 μl; administered into the abdomen of mice 1 hour before ISO injection) was able to attenuate the increase in serum CK-MB, LDH, and cTnT levels induced by ISO (100 mg/kg; subcutaneous injection; for 2 consecutive days) to create experimental myocardial infarction. Additionally, Cipepofol significantly improved ISO-induced left ventricular systolic and diastolic dysfunction[2]. |
Alias | HSK3486, HSK-3486, CS-0064163, HSK 3486 |
Molecular Weight | 204.31 |
Formula | C14H20O |
Cas No. | 1637741-58-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (391.56 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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