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Cipepofol
🥰Excellent
Catalog No. T32105Cas No. 1637741-58-2
Alias HSK-3486, HSK3486, HSK 3486, CS-0064163
Cipepofol (HSK3486) is a GABAA receptor agonist with sedative properties and protective effects in a variety of cardiovascular diseases.Cipepofol activates the Sirtuin1 (Sirt1)/Nrf2 pathway and induces apoptosis in cardiomyocytes, and can be used to study myocardial infarction, myocardial ischemia/reperfusion injury, and octopus pot syndrome.
Cipepofol
🥰Excellent
Purity: 99.77%
Catalog No. T32105Alias HSK-3486, HSK3486, HSK 3486, CS-0064163Cas No. 1637741-58-2
Cipepofol (HSK3486) is a GABAA receptor agonist with sedative properties and protective effects in a variety of cardiovascular diseases.Cipepofol activates the Sirtuin1 (Sirt1)/Nrf2 pathway and induces apoptosis in cardiomyocytes, and can be used to study myocardial infarction, myocardial ischemia/reperfusion injury, and octopus pot syndrome.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $83 | In Stock | |
| 5 mg | $187 | In Stock | |
| 10 mg | $293 | In Stock | |
| 25 mg | $589 | In Stock | |
| 50 mg | $965 | In Stock | |
| 100 mg | $1,530 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $188 | In Stock |
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Purity:99.77%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Cipepofol (HSK3486) is a GABAA receptor agonist with sedative properties and protective effects in a variety of cardiovascular diseases.Cipepofol activates the Sirtuin1 (Sirt1)/Nrf2 pathway and induces apoptosis in cardiomyocytes, and can be used to study myocardial infarction, myocardial ischemia/reperfusion injury, and octopus pot syndrome. |
| In vitro | Cipepofol (5 μM; administered before ISO injury; for 6 hours) can attenuate ISO-induced apoptosis in cultured cardiomyocytes in vitro[2]. |
| In vivo | In eighty male C57BL/6 mice (20-24 g, 8-10 weeks old), Cipepofol (100 μl; administered into the abdomen of mice 1 hour before ISO injection) was able to attenuate the increase in serum CK-MB, LDH, and cTnT levels induced by ISO (100 mg/kg; subcutaneous injection; for 2 consecutive days) to create experimental myocardial infarction. Additionally, Cipepofol significantly improved ISO-induced left ventricular systolic and diastolic dysfunction[2]. |
| Alias | HSK-3486, HSK3486, HSK 3486, CS-0064163 |
| Molecular Weight | 204.31 |
| Formula | C14H20O |
| Cas No. | 1637741-58-2 |
| Smiles | [C@H](C)(C1=C(O)C(C(C)C)=CC=C1)C2CC2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (391.56 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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