Shopping Cart

Remove All

Your shopping cart is currently empty

Compound 48/80 trihydrochloride

Select Batch

Resource Download

COA

Compound 48/80 trihydrochloride

Catalog No. T13623Cas No. 848035-21-2

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde in a condensation reaction.Compound 48/80 trihydrochloride is a mast cell degranulator and histamine releaser. Compound 48/80 trihydrochloride inhibits phosphatidylinositol-specific phospholipase C activity in human platelets.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability	Quantity
5 mg	$49	Backorder
1 mL x 10 mM (in DMSO)	$98	Backorder

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "Compound 48/80 trihydrochloride"

Product Introduction

Bioactivity

Description	Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of N-methyl-p-methoxyphenethylamine and formaldehyde in a condensation reaction.Compound 48/80 trihydrochloride is a mast cell degranulator and histamine releaser. Compound 48/80 trihydrochloride inhibits phosphatidylinositol-specific phospholipase C activity in human platelets.
In vitro	Compound 48/80 trihydrochloride inhibits both cytosolic and particulate phosphatidylinositol-specific phospholipase C activities with similar efficiency (IC50s: 2.1 μg/ml (supernatant) and 5.0 μg /ml (particulate fraction)). The aggregation of human platelets induced by ADP and PAF-acether is inhibited by Compound 48/80 [1].
In vivo	Compound 48/80 trihydrochloride causes oxidative stress in the rat adrenal gland through mast cell degranulation. Compound 48/80 trihydrochloride (0.75 mg/kg; i.p.; Killed after 0.5, 3, or 6 h) increases serum serotonin, histamine, and corticosterone levels at 0.5 h, but their increases were reduced thereafter [3].
Alias	C48/80 trihydrochloride

Chemical Properties

Molecular Weight	629.1
Formula	C32H48Cl3N3O3
Cas No.	848035-21-2

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 12.58 mg/mL (20 mM)

DMSO: 6.29 mg/mL (10 mM)

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5896 mL	7.9479 mL	15.8957 mL	79.4786 mL
5 mM	0.3179 mL	1.5896 mL	3.1791 mL	15.8957 mL

H2O

	1mg	5mg	10mg	50mg
10 mM	0.1590 mL	0.7948 mL	1.5896 mL	7.9479 mL
20 mM	0.0795 mL	0.3974 mL	0.7948 mL	3.9739 mL
50 mM	0.0318 mL	0.1590 mL	0.3179 mL	1.5896 mL
100 mM	0.0159 mL	0.0795 mL	0.1590 mL	0.7948 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc