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cRIPGBM chloride
🥰Excellent
Catalog No. T72658Cas No. 2361988-77-2
cRIPGBM chloride is an apoptosis-promoting derivative present in GBM cancer stem cells with antitumor activity. It induces caspase-1 dependent cell apoptosis by interacting with receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch. cRIPGBM chloride reduces the formation of pro-survival RIPK2/TAK1 complexes and increases the formation of pro-apoptotic RIPK2/caspase 1 complexes, which can be used to study brain tumors.
cRIPGBM chloride
🥰Excellent
Catalog No. T72658Cas No. 2361988-77-2
cRIPGBM chloride is an apoptosis-promoting derivative present in GBM cancer stem cells with antitumor activity. It induces caspase-1 dependent cell apoptosis by interacting with receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch. cRIPGBM chloride reduces the formation of pro-survival RIPK2/TAK1 complexes and increases the formation of pro-apoptotic RIPK2/caspase 1 complexes, which can be used to study brain tumors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $64 | In Stock | |
| 10 mg | $106 | In Stock | |
| 25 mg | $185 | In Stock | |
| 50 mg | $273 | In Stock | |
| 100 mg | $395 | In Stock | |
| 200 mg | $589 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | cRIPGBM chloride is an apoptosis-promoting derivative present in GBM cancer stem cells with antitumor activity. It induces caspase-1 dependent cell apoptosis by interacting with receptor-interacting protein kinase 2 (RIPK2) and acting as a molecular switch. cRIPGBM chloride reduces the formation of pro-survival RIPK2/TAK1 complexes and increases the formation of pro-apoptotic RIPK2/caspase 1 complexes, which can be used to study brain tumors. |
| Targets&IC50 | GBM CSC cells:68 nM (EC50) |
| In vitro | cRIPGBM chloride induces Caspase-1 dependent apoptosis by binding to receptor interacting protein kinase 2 (RIPK2) and acting as a molecular switch, EC50 = 68 nM. Thus, the formation of pro-survival RIPK2/TAK1 complex was decreased and the formation of pro-apoptotic RIPK2/caspase 1 complex was increased. [1] |
| In vivo | In a mouse model of intracranial GBM CSC tumor xenotransplantation in situ, cRIPGBM chloride (20 mg/kg oral) was found to significantly inhibit tumor formation in vivo. [1] |
| Molecular Weight | 446.9 |
| Formula | C26H20ClFN2O2 |
| Cas No. | 2361988-77-2 |
| Smiles | [Cl-].O=C1C=2C=CC=CC2C(=O)C3=C1N(C(=[N+]3CC4=CC=C(F)C=C4)C)CC=5C=CC=CC5 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16 mg/mL (35.8 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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