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CX717
🥰Excellent
Catalog No. T60201Cas No. 867276-98-0
CX 717 is a positive allosteric modulator of the AMPA receptor with antidepressant-like effects and potential use in adult attention deficit hyperactivity disorder (ADHD) research [1] [2].
CX717
🥰Excellent
Purity: 100%
Catalog No. T60201Cas No. 867276-98-0
CX 717 is a positive allosteric modulator of the AMPA receptor with antidepressant-like effects and potential use in adult attention deficit hyperactivity disorder (ADHD) research [1] [2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $38 | In Stock | |
| 25 mg | $77 | In Stock | |
| 50 mg | $119 | In Stock | |
| 100 mg | $197 | In Stock | |
| 200 mg | $293 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CX 717 is a positive allosteric modulator of the AMPA receptor with antidepressant-like effects and potential use in adult attention deficit hyperactivity disorder (ADHD) research [1] [2]. |
| In vivo | CX 717 (CX717; 20 mg/kg) exhibits a rapid (30 min) but short-lasting (up to 24 h) antidepressant-like effect in the forced swim test. It swiftly increases brain-derived neurotrophic factor (BDNF) within 1 hour and sustains elevated p11 levels for up to 6 hours [2]. When infused intra-cortically at 85 mM, CX 717 enhances the efflux of noradrenaline, dopamine, and serotonin without altering glutamate levels [2]. Male Sprague-Dawley rats (280-350 g) received a dosage of 20 mg/kg (at 1 mL/kg) via intraperitoneal injection. Results indicated that CX 717 provoked antidepressant-like effects without changing extracellular noradrenaline (NA), dopamine (DA), serotonin (5-HT), and glutamate levels in the medial prefrontal cortex (mPFC) [2]. |
| Molecular Weight | 233.23 |
| Formula | C11H11N3O3 |
| Cas No. | 867276-98-0 |
| Smiles | O=C(N1CCOCC1)c1ccc2nonc2c1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (193 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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