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Cyclotriazadisulfonamide hydrochloride
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Catalog No. T39264LCas No. 392287-03-5
Alias Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)
Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
Cyclotriazadisulfonamide hydrochloride
😃Good
Catalog No. T39264LAlias Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)Cas No. 392287-03-5
Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | Backorder | |
| 5 mg | $437 | Backorder | |
| 10 mg | $655 | Backorder | |
| 25 mg | $1,178 | Backorder | |
| 50 mg | $1,768 | Backorder | |
| 100 mg | $2,652 | Backorder | |
| 200 mg | $3,978 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way. |
| In vitro | Cyclotriazadisulfonamide hydrochloride exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Cyclotriazadisulfonamide hydrochloride (10 μg/mL) results in 83% downregulation of cell surface CD4. Cyclotriazadisulfonamide hydrochloride prevents MT-4 cells from HIV-1 and SIV infection with EC50s of 0.7 and 1.2 g/ml, respectively. Cyclotriazadisulfonamide hydrochloride significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far[1]. |
| Alias | Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base) |
| Molecular Weight | 618.25 |
| Formula | C31H40ClN3O4S2 |
| Cas No. | 392287-03-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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