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Cyclotriazadisulfonamide hydrochloride

Catalog No. T39264LCas No. 392287-03-5

Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.

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Pack Size	Price	Availability
1 mg	$195	Backorder
5 mg	$437	Backorder
10 mg	$655	Backorder
25 mg	$1,178	Backorder
50 mg	$1,768	Backorder
100 mg	$2,652	Backorder
200 mg	$3,978	Backorder

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Product Introduction

Bioactivity

Description	Cyclotriazadisulfonamide hydrochloride is a selective inhibitor of CD4-targeted HIV entry and inhibits the co-translational translocation of human CD4 into the ER lumen in a signal peptide-dependent way.
In vitro	Cyclotriazadisulfonamide hydrochloride exhibits an EC50 of 0.4 μg/mL for CD4 in MO-DC cells. Cyclotriazadisulfonamide hydrochloride (10 μg/mL) results in 83% downregulation of cell surface CD4. Cyclotriazadisulfonamide hydrochloride prevents MT-4 cells from HIV-1 and SIV infection with EC50s of 0.7 and 1.2 g/ml, respectively. Cyclotriazadisulfonamide hydrochloride significantly decreases the amount of cell surface CD4 -the main receptor for HIV -without altering the expression of any other cellular receptor examined so far[1].
Alias	Cyclotriazadisulfonamide hydrochloride (182316-44-5 Free base)

Chemical Properties

Molecular Weight	618.25
Formula	C31H40ClN3O4S2
Cas No.	392287-03-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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