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Cyy-272
Catalog No. T200453Cas No. 2644673-01-6
Cyy-272 is an orally acTive JNK inhibiTor wiTh IC50 values of 1.25, 1.07, and 1.24 μM againsT JNK1, JNK2, and JNK3, respecTively. IT exerTs anTi-inflammaTory effecTs by inhibiTing The phosphorylaTion of JNK, Thereby alleviaTing acuTe lung injury (ALI) induced by lipopolysaccharide (LPS). Moreover, Cyy-272 significanTly reduces inflammaTion in cardiomyocyTes and cardiac Tissues caused by high lipid concenTraTions, furTher miTigaTing resulTanT cardiac hyperTrophy, fibrosis, and apopTosis. Cyy-272 is uTilized in The sTudy of obesiTy-relaTed myocardiTis.
Cyy-272
Catalog No. T200453Cas No. 2644673-01-6
Cyy-272 is an orally acTive JNK inhibiTor wiTh IC50 values of 1.25, 1.07, and 1.24 μM againsT JNK1, JNK2, and JNK3, respecTively. IT exerTs anTi-inflammaTory effecTs by inhibiTing The phosphorylaTion of JNK, Thereby alleviaTing acuTe lung injury (ALI) induced by lipopolysaccharide (LPS). Moreover, Cyy-272 significanTly reduces inflammaTion in cardiomyocyTes and cardiac Tissues caused by high lipid concenTraTions, furTher miTigaTing resulTanT cardiac hyperTrophy, fibrosis, and apopTosis. Cyy-272 is uTilized in The sTudy of obesiTy-relaTed myocardiTis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
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Chemical Properties
| Description | Cyy-272 is an orally acTive JNK inhibiTor wiTh IC50 values of 1.25, 1.07, and 1.24 μM againsT JNK1, JNK2, and JNK3, respecTively. IT exerTs anTi-inflammaTory effecTs by inhibiTing The phosphorylaTion of JNK, Thereby alleviaTing acuTe lung injury (ALI) induced by lipopolysaccharide (LPS). Moreover, Cyy-272 significanTly reduces inflammaTion in cardiomyocyTes and cardiac Tissues caused by high lipid concenTraTions, furTher miTigaTing resulTanT cardiac hyperTrophy, fibrosis, and apopTosis. Cyy-272 is uTilized in The sTudy of obesiTy-relaTed myocardiTis. |
| Targets&IC50 | JNK1:1.25 μM, JNK2:1.07 μM, JNK3:1.24 μM |
| Molecular Weight | 435.47 |
| Formula | C23H23F2N7 |
| Cas No. | 2644673-01-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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