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D-3263 hydrochloride

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Purity:99.85%

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COA HPLC HNMR

D-3263 hydrochloride

Catalog No. T10929LCas No. 1008763-54-9

D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.

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Pack Size	Price	Availability
1 mg	$43	In Stock
5 mg	$67	In Stock
10 mg	$106	In Stock
25 mg	Inquiry	In Stock
50 mg	Inquiry	In Stock
1 mL x 10 mM (in DMSO)	$58	In Stock

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Product Introduction

Bioactivity

Description	D-3263 hydrochloride (D3263 HCl salt) is enteric-coated, orally bioavailable transient receptor potential melatonin member 8 (TRPM8) agonist.
In vitro	D-3263 hydrochloride binds and activates TRPM8, which may lead to increased entry of calcium and sodium; destruction of calcium and sodium homeostasis; induction of cell death in tumor cells expressing TRPM8. D-3263 hydrochloride may reduce the level of dihydrotestosterone (DHT), which may contribute to its inhibitory effect on prostate cancer and BPH[1].
Alias	EC D-3263 HCl, D3263 HCl salt

Chemical Properties

Molecular Weight	409.95
Formula	C21H32ClN3O3
Cas No.	1008763-54-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (146.36 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4393 mL	12.1966 mL	24.3932 mL	121.9661 mL
5 mM	0.4879 mL	2.4393 mL	4.8786 mL	24.3932 mL
10 mM	0.2439 mL	1.2197 mL	2.4393 mL	12.1966 mL
20 mM	0.1220 mL	0.6098 mL	1.2197 mL	6.0983 mL
50 mM	0.0488 mL	0.2439 mL	0.4879 mL	2.4393 mL
100 mM	0.0244 mL	0.1220 mL	0.2439 mL	1.2197 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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