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D159687
🥰Excellent
Catalog No. T5474Cas No. 1155877-97-6
Alias D 159687
D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit.
D159687
🥰Excellent
Purity: 97.57%
Catalog No. T5474Alias D 159687Cas No. 1155877-97-6
D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $30 | In Stock | |
| 10 mg | $46 | In Stock | |
| 25 mg | $98 | In Stock | |
| 50 mg | $158 | In Stock | |
| 100 mg | $253 | In Stock | |
| 200 mg | $376 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $31 | In Stock |
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Purity:97.57%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit. |
| In vitro | D159687 induced a transient increase in CREB phosphorylation which peaked at 6 hrs after treatment ( F (3, 20) = 3.731, P = 0.0425). CREB phosphorylation was optimal at 1 μM ( F (3, 20) = 4.194, P = 0.0302). |
| Cell Research | cAMP concentrations were measured using the enzyme-linked immunosorbent assay.?On the day of treatment, the attached HT-22 cells were washed with warm phosphate buffer saline and then incubated for 10 min with PBS supplemented with various concentrations of D159687 and further for 10 min with 10 nM isoproterenol in the system52.?After incubation, PBS containing the drugs was removed and the plates were let dry roughly before 200 μl HCl (0.1 M) was added to each well to lyse the cells.?Cell lysates were collected into Eppendorf tubes and centrifuged at 800 g for 15 min. Supernatants were collected for immediate assay or stored frozen for assay later using the cAMP complete ELISA kit according to the assay protocol. |
| Alias | D 159687 |
| Molecular Weight | 366.84 |
| Formula | C21H19ClN2O2 |
| Cas No. | 1155877-97-6 |
| Smiles | COc1ccc(Cc2ccc(NC(N)=O)cc2)cc1-c1cccc(Cl)c1 |
| Relative Density. | 1.263 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 150 mg/mL (408.90 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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