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DCC-3116

Catalog No. T86167Cas No. 2543673-19-2
Alias DCC3116

DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.

DCC-3116

DCC-3116

Purity: 98.80%
Catalog No. T86167Alias DCC3116Cas No. 2543673-19-2
DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.
Pack SizePriceAvailabilityQuantity
1 mg$195In Stock
5 mg$483In Stock
10 mg$692In Stock
25 mg$1,080In Stock
50 mg$1,490In Stock
100 mg$1,970In Stock
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Purity:98.80%
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Product Introduction

Bioactivity
Description
DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.
In vitro
100 nM DCC-3116 alone inhibited NCI-H2122 and Calu-1 cell proliferation and reduced pS318-ATG13 expression, and DCC-3116 in combination with sotorasib showed synergistic inhibition of human lung cancer cell proliferation driven by the KRAS G12C mutation in vitro. [1]
In vivo
Daily oral or intraperitoneal administration of 3 or 30 mg/kg DCC-3116 for 56 consecutive days alone or in combination with Sotorasib inhibited tumor growth in a mouse model of NSCLC lung cancer. [1]
AliasDCC3116
Chemical Properties
Molecular Weight535.61
FormulaC26H36F3N7O2
Cas No.2543673-19-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL(186.71 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8670 mL9.3352 mL18.6703 mL93.3515 mL
5 mM0.3734 mL1.8670 mL3.7341 mL18.6703 mL
10 mM0.1867 mL0.9335 mL1.8670 mL9.3352 mL
20 mM0.0934 mL0.4668 mL0.9335 mL4.6676 mL
50 mM0.0373 mL0.1867 mL0.3734 mL1.8670 mL
100 mM0.0187 mL0.0934 mL0.1867 mL0.9335 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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