Shopping Cart
- Remove All
- Your shopping cart is currently empty
DDX3-IN-2 is an ATP-dependent RNA deconjugase (DDX3) inhibitor with broad-spectrum antiviral activity and is used in the study of HIV infection and dengue virus infection.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $116 | In Stock | |
1 mL x 10 mM (in DMSO) | $196 | 5 days |
Description | DDX3-IN-2 is an ATP-dependent RNA deconjugase (DDX3) inhibitor with broad-spectrum antiviral activity and is used in the study of HIV infection and dengue virus infection. |
Targets&IC50 | DEADbox polypeptide 3 (DDX3):0.3 μM |
In vitro | DDX3-IN-2 is a competitive inhibitor of RNA substrates, and its inhibitory potency decreases with increasing RNA substrate concentration. DDX3-IN-2 was shown to be a potent inhibitor of DEADbox polypeptide 3 (DDX3) with an IC50 of 0.3 μM, and DDX3-IN-2 was inactive against the ATPase activity of DDX3, DDX1 deconjugating enzyme and DENV NS3 deconjugating enzyme. [1] |
In vivo | In animal studies, DDX3-IN-2 was administered via tail vein injection at a dose of 20 mg/kg, which showed good biocompatibility and was well tolerated by Wistar rats. DDX3-IN-2 rapidly shortens the half-life and decreases plasma clearance in an intravenous push (0-25 hours) at a dose of 10 mg/kg. [1] |
Molecular Weight | 349.43 |
Formula | C20H23N5O |
Cas No. | 1919828-81-1 |
Smiles | O=C(NC1=CC=C(C=C1)N2N=NC(=C2)CCCC)NC=3C=CC=CC3C |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (228.94 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.