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DDX3-IN-2

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Catalog No. T61193Cas No. 1919828-81-1

DDX3-IN-2 is an ATP-dependent RNA deconjugase (DDX3) inhibitor with broad-spectrum antiviral activity and is used in the study of HIV infection and dengue virus infection.

DDX3-IN-2

DDX3-IN-2

😃Good
Catalog No. T61193Cas No. 1919828-81-1
DDX3-IN-2 is an ATP-dependent RNA deconjugase (DDX3) inhibitor with broad-spectrum antiviral activity and is used in the study of HIV infection and dengue virus infection.
Pack SizePriceAvailabilityQuantity
2 mg$116In Stock
1 mL x 10 mM (in DMSO)$1965 days
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Product Introduction

Bioactivity
Description
DDX3-IN-2 is an ATP-dependent RNA deconjugase (DDX3) inhibitor with broad-spectrum antiviral activity and is used in the study of HIV infection and dengue virus infection.
Targets&IC50
DEADbox polypeptide 3 (DDX3):0.3 μM
In vitro
DDX3-IN-2 is a competitive inhibitor of RNA substrates, and its inhibitory potency decreases with increasing RNA substrate concentration. DDX3-IN-2 was shown to be a potent inhibitor of DEADbox polypeptide 3 (DDX3) with an IC50 of 0.3 μM, and DDX3-IN-2 was inactive against the ATPase activity of DDX3, DDX1 deconjugating enzyme and DENV NS3 deconjugating enzyme. [1]
In vivo
In animal studies, DDX3-IN-2 was administered via tail vein injection at a dose of 20 mg/kg, which showed good biocompatibility and was well tolerated by Wistar rats. DDX3-IN-2 rapidly shortens the half-life and decreases plasma clearance in an intravenous push (0-25 hours) at a dose of 10 mg/kg. [1]
Chemical Properties
Molecular Weight349.43
FormulaC20H23N5O
Cas No.1919828-81-1
SmilesO=C(NC1=CC=C(C=C1)N2N=NC(=C2)CCCC)NC=3C=CC=CC3C
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (228.94 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8618 mL14.3090 mL28.6180 mL143.0902 mL
5 mM0.5724 mL2.8618 mL5.7236 mL28.6180 mL
10 mM0.2862 mL1.4309 mL2.8618 mL14.3090 mL
20 mM0.1431 mL0.7155 mL1.4309 mL7.1545 mL
50 mM0.0572 mL0.2862 mL0.5724 mL2.8618 mL
100 mM0.0286 mL0.1431 mL0.2862 mL1.4309 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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