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Dehydro Nifedipine

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Purity:98.65%

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COA HPLC HNMR

Dehydro Nifedipine

Catalog No. T36665Cas No. 67035-22-7

Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.

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Pack Size	Price	Availability
1 mg	$50	In Stock
5 mg	$125	In Stock
10 mg	$188	In Stock
50 mg	$470	In Stock

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Related Compound Libraries of "Dehydro Nifedipine"

Product Introduction

Bioactivity

Description	Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.
In vitro	Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM[1].
Alias	BAY-b 4759

Chemical Properties

Molecular Weight	344.32
Formula	C17H16N2O6
Cas No.	67035-22-7

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 2.7 mg/mL (7.8 mM)

DMSO: 27.0 mg/mL (78.5 mM)

DMF: 30 mg/mL

DMSO:PBS (pH 7.2) (1:10): 0.1 mg/mL

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.9043 mL	14.5214 mL	29.0428 mL	145.2138 mL
5 mM	0.5809 mL	2.9043 mL	5.8086 mL	29.0428 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2904 mL	1.4521 mL	2.9043 mL	14.5214 mL
20 mM	0.1452 mL	0.7261 mL	1.4521 mL	7.2607 mL
50 mM	0.0581 mL	0.2904 mL	0.5809 mL	2.9043 mL
100 mM	0.0290 mL	0.1452 mL	0.2904 mL	1.4521 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc