Shopping Cart
- Remove All
Your shopping cart is currently empty
Dehydro Nifedipine
🥰Excellent
Catalog No. T36665Cas No. 67035-22-7
Alias BAY-b 4759
Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.
Dehydro Nifedipine
🥰Excellent
Purity: 98.65%
Catalog No. T36665Alias BAY-b 4759Cas No. 67035-22-7
Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $50 | In Stock | |
| 5 mg | $125 | In Stock | |
| 10 mg | $188 | In Stock | |
| 50 mg | $470 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Dehydro Nifedipine"
Isonicotinic acid
Fr1375655-22-1
Isonicotinic acid, a metabolite of isoniazid and a useful isomer of nicotinic acid, is formed from isoniazid by hydrazinolysis and can be catalyzed by cytochrome P450 enzymes, such as CYP2C.
- $53
Size
QTY
Mycophenolate Mofetil
TM-MMF, RS 61443
T6293128794-94-5
Mycophenolate Mofetil (TM-MMF), an immunosuppressive agent, is the 2-morpholinoethyl ester of mycophenolic acid (MPA), and an inhibitor of inosine monophosphate dehydrogenase (IMPDH).
- $47
Size
QTY
CLOZAPINE N-OXIDE
Cited
T449434233-69-7
Clozapine N-oxide is the major metabolite of Clozapine and is blood-brain barrier permeable. Clozapine N-oxide is an agonist of DREADDs and activates the DREADD receptors hM3Dq and hM4Di. Clozapine N-oxide is also a dopamine antagonist and selective muscarinic M4 receptor agonist.
- $30
Size
QTY
CitedAmpyrone
Solnapyrin-A, NSC 60242, Minoazophene, Aminoantipyrin, 4-Aminoantipyrine
T005083-07-8
Ampyrone (4-Aminoantipyrine) is a reagent for glucose determination in the presence of peroxidase and phenol.
- $35
Size
QTY
Nicotinamide N-oxide
Nicotinamide-N-oxide, Nicotinamide 1-oxide, 1-oxynicotinamide
T06171986-81-8
Nicotinamide N-oxide (Nicotinamide 1-oxide) is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase.
- $33
Size
QTY
Monomethyl fumarate
T120952756-87-8
Monomethyl fumarate is a potent agonist of GPR109A .
- $42
Size
QTY
Clofibric acid Cited
Chlorofibrinic acid
T0061882-09-7
Clofibric acid (Chlorofibrinic acid) is an antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
- $31
Size
QTY
Cited4-Methylamino antipyrine
T10152519-98-2
4-Methylamino antipyrine, an active metabolite of Metamizole, a pyrazolone non-steroidal anti-inflammatory drug (NSAID) that inhibits COX, possesses analgesic, antipyretic, and relatively weak anti-inflammatory properties.
- $39
Size
QTY
Oseltamivir acid Cited
Ro 64-0802, oseltamivir carboxylate, GS 4071
T5186187227-45-8
Oseltamivir acid (GS4071) is a potent influenza virus neuraminidase inhibitor and the prodrug of GS4071.
- $30
Size
QTY
CitedNortriptyline hydrochloride Cited
EN-7048 hydrochloride, ELF-101 hydrochloride, Desmethylamitriptyline hydrochloride, Desitriptyline HCl
T1327894-71-3
Nortriptyline hydrochloride (ELF-101 hydrochloride) is a metabolite of AMITRIPTYLINE that is also used as an antidepressive agent. Nortriptyline is used in major depression, dysthymia, and atypical depressions.
5-HT ReceptorAChRAdrenergic ReceptorApoptosisAutophagyDopamine ReceptorDrug MetaboliteHistamine ReceptorNorepinephrine
- $33
Size
QTY
CitedDP-1 hydrochloride
DP-1 hydrochloride(1472616-61-7 Free base)
T38961L1472616-35-5In house
DP-1 hydrochloride is a degradation product of SDC-TRAP-0063, a fragment of Ganetespib, a heat shock protein 90 (HSP90) inhibitor with antitumor activity.
- $172
Size
QTY
3-Methoxytyramine hydrochloride
3-O-methyl Dopamine hydrochloride), 3-O-methyl Dopamine hydrochloride
T47101477-68-5
3-Methoxytyramine hydrochloride (3-O-methyl Dopamine hydrochloride) is an inactive metabolite of dopamine which can activate trace amine associated receptor 1 (TAAR1). 3-methoxytyramine can be found primarily in human brain and most tissues tissues; and in blood, cerebrospinal fluid (csf) or urine. Within a cell, 3-methoxytyramine is primarily located in the cytoplasm.
- $42
Size
QTY
Select Batch
Purity:98.65%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Dehydro Nifedipine (BAY-b 4759) is the main metabolite of nifedipine in human plasma. Dehydro Nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM. Nifedipine is a calcium channel blocker used in the treatment of hypertension and angina. Dehydronifedipine is formed when it is metabolized by cytochrome P450 (CYP) isomers CYP3A4 and CYP3A5. |
| Targets&IC50 | Glucose uptake:130 μM |
| In vitro | Dehydro nifedipine inhibits glucose uptake in PC-12 cells with an IC50 value of 130 μM[1]. |
| Alias | BAY-b 4759 |
| Molecular Weight | 344.32 |
| Formula | C17H16N2O6 |
| Cas No. | 67035-22-7 |
| Smiles | COC(=O)c1c(C)nc(C)c(C(=O)OC)c1-c1ccccc1[N+]([O-])=O |
| Relative Density. | 1.284 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 2.7 mg/mL (7.8 mM) DMSO: 27.0 mg/mL (78.5 mM) DMF: 30 mg/mL DMSO:PBS (pH 7.2) (1:10): 0.1 mg/mL | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Dehydro Nifedipine | purchase Dehydro Nifedipine | Dehydro Nifedipine cost | order Dehydro Nifedipine | Dehydro Nifedipine chemical structure | Dehydro Nifedipine in vitro | Dehydro Nifedipine formula | Dehydro Nifedipine molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.