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Product Introduction

Bioactivity

Description	Dehydrocholic acid (Dehystolin) is a synthetic bile acid, produced by the oxidation of cholic acid.
In vivo	DHCA (dehydrocholic acid) infusion induces choleresis associated with reduced secretion of endogenous and/or exogenous biliary components[1].
Alias	Sanocholen, Felacrinos, Dehystolin, Decholin

Chemical Properties

Molecular Weight	402.52
Formula	C₂₄H₃₄O₅
Cas No.	81-23-2
Smiles	CC(CCC(O)=O)C1CCC2C3C(CC(=O)C12C)C1(C)CCC(=O)CC1CC3=O
Relative Density.	1.0687 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 12 mg/mL (29.8 mM)

DMSO: 45 mg/mL (111.8 mM)

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4843 mL	12.4217 mL	24.8435 mL	124.2174 mL
5 mM	0.4969 mL	2.4843 mL	4.9687 mL	24.8435 mL
10 mM	0.2484 mL	1.2422 mL	2.4843 mL	12.4217 mL
20 mM	0.1242 mL	0.6211 mL	1.2422 mL	6.2109 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0497 mL	0.2484 mL	0.4969 mL	2.4843 mL
100 mM	0.0248 mL	0.1242 mL	0.2484 mL	1.2422 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitDehydrocholic acid